{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:21:33Z","timestamp":1761895293347},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T00:00:00Z","timestamp":1309305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Elevated admission glucose level is a strong predictor of short\u2010term adverse outcome in patients with acute coronary syndrome (ACS). However, the prognostic value of diabetic control (ie, hemoglobin A<jats:sub>1c<\/jats:sub> levels) in patients with ACS is still undefined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis:<\/jats:title><jats:p>Hemoglobin A<jats:sub>1c<\/jats:sub> level may predict short\u2010term outcome in patients with ACS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We conducted a retrospective study with prospective follow\u2010up in 317 diabetic patients with ACS. Patients were stratified into 2 groups based on HbA<jats:sub>1c<\/jats:sub> level, checked within 8 weeks of the index admission (optimal control group, HbA<jats:sub>1c<\/jats:sub> \u22647%; suboptimal control group, HbA<jats:sub>1c<\/jats:sub> &gt;7%). All patients were followed up prospectively for major adverse cardiovascular events (MACE) and mortality for 6 months. Short\u2010term clinical outcomes were also compared between the 2 study groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>In our cohort, 27.4%, 46.4%, and 26.2% patients had unstable angina, non\u2013ST\u2010segment elevation myocardial infarction, and ST\u2010segment elevation myocardial infarction, respectively. In\u2010hospital mortality was similar in both HbA<jats:sub>1c<\/jats:sub> groups (3.37% vs 2.88%, <jats:italic>P<\/jats:italic> = 0.803). Six\u2010month MACE was also similar (26.40% vs 26.47%, <jats:italic>P<\/jats:italic> = 0.919). All\u2010cause mortality, cardiovascular mortality, symptom\u2010driven revascularization, rehospitalization for angina, and hospitalization for heart failure were also similar in both groups. The hazard ratios for 6\u2010month MACE and individual endpoints were also similar in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>This study suggests that HbA<jats:sub>1c<\/jats:sub> levels before admission are not associated with short\u2010term cardiovascular outcome in diabetic patients subsequently admitted with ACS. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><jats:p>The authors have no funding, financial relationships, or conflicts of interest to disclose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.20915","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T15:12:48Z","timestamp":1309446768000},"page":"507-512","source":"Crossref","is-referenced-by-count":19,"title":["The Value of Admission HbA<sub>1c<\/sub> Level in Diabetic Patients With Acute Coronary Syndrome"],"prefix":"10.1002","volume":"34","author":[{"given":"Chi Yuen","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph Yat Sun","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin Pang","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan P.","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yat\u2010Yin","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheuk\u2010Man","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1979.03290450033020"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.16.2.434"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(97)70222-9"},{"key":"e_1_2_6_5_2","first-page":"88","article-title":"Guidelines on diabetes, pre\u2010diabetes, and cardiovascular diseases: executive summary. 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