{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:59:34Z","timestamp":1761101974380},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T00:00:00Z","timestamp":1309305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Pulmonary arterial hypertension (PAH) is a well\u2010known complication of systemic sclerosis (SSc). Doppler echocardiographic screening for the detection of PAH (by measuring right ventricular systolic pressure [RVSP]) is therefore recommended for all patients with SSc. However, the validity of RVSP as a predictor of mortality in patients with SSc is not well established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis:<\/jats:title><jats:p>Doppler\u2010determined PAH identifies a high\u2010risk subset of patients with SSc with decreased survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We performed echocardiography in 155 consecutive patients with SSc between May 2005 and July 2006 and tested the value of an RVSP level of \u226536 mm Hg to predict mortality. Cox proportional hazards model was used to examine the individual relationship between each variable and the mortality rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Tricuspid regurgitant jets for RVSP determination were quantified in 129 patients (82.6%), of which 47 (36.4%) had RVSP \u226536 mm Hg. The median follow\u2010up time was 34 months. The 1\u2010, 2\u2010, and 3\u2010year survival rates were significantly lower among SSc patients with RVSP \u226536 vs \u226436 mm Hg (82%, 78%, and 67% vs 98%, 90%, and 86%, respectively, <jats:italic>P &lt;<\/jats:italic> 0.01 by Wilcoxon test). In a multivariate analysis including echocardiographic and clinical variables, only an RVSP \u226536 mm Hg and a New York Heart Association III\/IV class were associated with increased mortality; the respective Cox hazard ratios were 2.22 (95% confidence interval [CI]: 1.01\u20134.89, <jats:italic>P<\/jats:italic> = 0.048) and 4.77 (95% CI: 2.09\u201310.90, <jats:italic>P<\/jats:italic> = 0.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Our results indicate that Doppler RVSP identifies a high\u2010risk subset and supports the use of Doppler RVSP as a screening test in patients with SSc who may warrant early treatment of their PAH. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><jats:p>The authors have no funding, financial relationships, or conflicts of interest to disclose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.20920","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T15:21:23Z","timestamp":1309447283000},"page":"488-493","source":"Crossref","is-referenced-by-count":14,"title":["Right Ventricular Systolic Pressure Assessed by Echocardiography: A Predictive Factor of Mortality in Patients With Scleroderma"],"prefix":"10.1002","volume":"34","author":[{"given":"Songsak","family":"Kiatchoosakun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaiyasith","family":"Wongvipaporn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratanavadee","family":"Nanagara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian 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