{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:05:30Z","timestamp":1700525130165},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>A low level of high\u2010density lipoprotein cholesterol (HDL\u2010C) is a strong predictor for cardiovascular disease morbidity and mortality at all low\u2010density lipoprotein cholesterol (LDL\u2010C) concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis:<\/jats:title><jats:p>We evaluated this association in routine clinical practice among statin\u2010treated coronary heart disease patients who achieved LDL\u2010C target levels. This association also exists in routine clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>A retrospective dynamic cohort included all male coronary heart disease patients of the Sharon\u2010Shomron district, Clalit Health Services, Israel, with LDL\u2010C levels &lt;100 mg\/dL and who were receiving statins (\u22656 purchases\/y) from January 1998 to June 2008. Data were collected on demographic variables; coexistence of hypertension, diabetes mellitus, and peripheral vascular diseases; details of revascularization procedures; and lipid levels. The outcome variable was revascularization procedure, by either percutaneous intervention or coronary artery bypass graft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The study group of 909 male patients was stratified into quintiles, based on mean HDL\u2010C levels: Q1 (n = 179): \u226426.4 mg\/dL; Q2 (n = 190): 26.4\u2013\u226430.0 mg\/dL; Q3 (n = 191): &gt;30.0\u2013\u226434.0 mg\/dL; Q4 (n = 186): &gt;34.0\u2013\u226441.0 mg\/dL; Q5 (n = 163): &gt;41.0 mg\/dL. During the study period, 307 (33.8%) of the cohort required \u22651 revascularization procedure. Those in the highest quintile underwent significantly fewer procedures (40.8% for Q1 vs 16.6% for Q5, <jats:italic>P&lt;<\/jats:italic>0.001). This significant effect of the highest HDL\u2010C quintile was not influenced by any variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The protective effect of high HDL\u2010C levels, regardless of other risk factors, in preventing revascularization procedures was confirmed in the routine clinical practice among statin\u2010treated CHD patients who reached LDL\u2010C level &lt;100 mg\/dL. Possible additional benefits of using agents to raise HDL\u2010C levels should be investigated. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><jats:p>The authors have no funding, financial relationships, or conflicts of interest to disclose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.20944","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T21:46:13Z","timestamp":1314913573000},"page":"572-576","source":"Crossref","is-referenced-by-count":3,"title":["HDL\u2010C Levels and Revascularization Procedures in Coronary Heart Disease Patients Treated With Statins to Target LDL\u2010C Levels"],"prefix":"10.1002","volume":"34","author":[{"given":"Avishay","family":"Elis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pereg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Froom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lishner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Segev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doron","family":"Hermoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133317.49796.0E"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380200073024"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-004-0055-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/138945007780058933"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90874-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.1.8"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198911093211907"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa064278"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.09.087"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.086"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60713-1"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.3.839"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.5.499"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.17.2292"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907569"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543770903198451"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009744"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001689"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.20944","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.20944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T11:18:32Z","timestamp":1700479112000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.20944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1002\/clc.20944"],"URL":"https:\/\/doi.org\/10.1002\/clc.20944","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}