{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:12Z","timestamp":1786977492146,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,6]],"date-time":"2012-04-06T00:00:00Z","timestamp":1333670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Clinical outcomes of percutaneous coronary intervention (PCI) in patients with saphenous vein grafts (SVGs) remain poor despite the use of drug\u2010eluting stents (DES). There is a disparity in clinical outcomes in SVG PCI based on various registries, and randomized clinical data remain scant. We conducted a meta\u2010analysis of all existing randomized controlled trials (RCTS) comparing bare\u2010metal stents (BMS) and DES in SVGPCIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis:<\/jats:title>\n                    <jats:p>PCI in patients with SVG disease using DES may reduce need for repeat revascularization without an excess mortality when compared to BMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>An aggregate data meta\u2010analysis of clinical outcomes in RCTs comparing PCI with DES vs BMS for SVGs reporting at least 12 months of follow\u2010up was performed. A literature search between Janurary 1, 2003 and September 30, 2011 identified 4 RCTs (812 patients; DES = 416, BMS = 396). Summary odds ratio (OR) and 95% confidence interval (CI) were calculated using the random\u2010effects model. The primary endpoint was all\u2010cause mortality. Secondary outcomes included nonfatal myocardial infarction (MI), repeat revascularization, and major adverse cardiac events (MACE). These outcomes were assessed in a cumulative fashion at 30 days, 18 months, and 36 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There were no intergroup differences in baseline clinical and sociodemographic characteristics. At a median follow\u2010up of 25 months, patients in the DES and BMS group had similar rates of death (OR: 1.63, 95% CI: 0.45\u20135.92), MI (OR; 0.83, 95% CI: 0.27\u20102.60), and MACE (OR: 0.58, 95% CI: 0.25\u20131.32). Patients treated with DES had lower rates of repeat revascularization (OR: 0.40, 95% CI: 0.22\u20130.75).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      In this comprehensive meta\u2010analysis of all RCTs comparing clinical outcomes of PCI using DES vs BMS in patients with SVG disease, use of DES was associated with a reduction in rate of repeat revascularization and no difference in rates of all\u2010cause death and MI.\n                      <jats:italic>Clin. Cardiol.<\/jats:italic>\n                      2012 DOI: 10.1002\/clc.21984\n                    <\/jats:p>\n                    <jats:p>Dr. Virani is supported by a Department of Veterans Affairs Health Services Research and Development Service (HSR&amp;D) Career Development Award (CDA\u201009\u2010028), and has research support from Merck and National Football League Charities (all grants to the institution and not individual). The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs. The authors have no other funding, financial relationships, or conflicts of interest to disclose.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.21984","type":"journal-article","created":{"date-parts":[[2012,4,7]],"date-time":"2012-04-07T23:03:47Z","timestamp":1333839827000},"page":"291-296","source":"Crossref","is-referenced-by-count":18,"title":["Clinical Outcomes of Percutaneous Interventions in Saphenous Vein Grafts Using Drug\u2010Eluting Stents Compared to Bare\u2010Metal Stents: A Comprehensive Meta\u2010Analysisof All Randomized Clinical Trials"],"prefix":"10.1002","volume":"35","author":[{"given":"Mahboob","family":"Alam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman J.","family":"Bandeali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim S.","family":"Virani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani M.","family":"Jneid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima A.","family":"Shahzad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kodangudi B.","family":"Ramanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswajit","family":"Kar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal S.","family":"Kleiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Lakkis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.651232"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","unstructured":"HakeemA HelmyT MunsifS et al. Safety and efficacy of drug eluting stents compared with bare metal stents for saphenous vein graft interventions: a comprehensive meta\u2010analysis of randomized trials and observational studies comprising 7 994 patients.CatheterCardiovascInterv.2011;77:343\u2013355.","DOI":"10.1002\/ccd.22720"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-7-199510010-00009"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.07.009"},{"key":"e_1_2_6_6_2","first-page":"172","article-title":"A comparison of drug\u2010eluting stents versus bare metal stents in saphenous vein graft PCI outcomes: a meta\u2010analysis.","volume":"24","author":"Mamas MA","year":"2011","journal-title":"J IntervCardiol."},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.08.019"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0186"},{"key":"e_1_2_6_9_2","first-page":"565","article-title":"Drug\u2010eluting or bare metal stents for the treatment of saphenous vein graft disease: a Bayesian meta\u2010analysis.","volume":"3","author":"Paradis JM","year":"2010","journal-title":"CircCardiovascInterv."},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ30V6I4A87"},{"key":"e_1_2_6_11_2","first-page":"e11040","article-title":"Drug\u2010eluting versus bare\u2010metal stent for treatment of saphenous vein grafts: a meta\u2010analysis.","volume":"2010","author":"Meier P","journal-title":"PLoS One."},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV6I1A22"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.12.006"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","unstructured":"VermeerschP AgostoniP VerheyeS et al. Randomized double\u2010blind comparison of sirolimus\u2010eluting stent versus bare\u2010metal stent implantation in diseased saphenous vein grafts: six\u2010month angiographic intravascular ultrasound and clinical follow\u2010up of the RRISC Trial.J Am CollCardiol.2006;48:2423\u20132431.","DOI":"10.1016\/j.jacc.2006.09.021"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.11.029"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.05.010"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.10.003"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000137699"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61255-5"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.21984","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.21984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T05:21:38Z","timestamp":1700544098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.21984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,6]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1002\/clc.21984"],"URL":"https:\/\/doi.org\/10.1002\/clc.21984","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,6]]}}}