{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:36:26Z","timestamp":1771472186583,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T00:00:00Z","timestamp":1333929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>This prospective study investigated the association between preprocedural biomarker levels and incident major adverse cardiac events (MACE) in complex patients undergoing percutaneous coronary intervention (PCI) with sirolimus\u2010eluting stenting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis:<\/jats:title><jats:p>Lipoprotein(a) (Lp[a]), interleukin\u201010 (IL\u201010), and high\u2010sensitivity C\u2010reactive protein (CRP) have long\u2010term prognostic value in patients undergoing PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Between April 2002 and February 2003, 161 patients were included in the study. Blood was drawn before the procedure, and biomarkers were measured. Patients were followed\u2010up for MACE (death, nonfatal myocardial infarction, and repeat revascularization). Cox proportional hazard models were used to determine risk of MACE for tertiles of biomarkers. Both 1\u2010year and long\u2010term follow\u2010up (median, 6 years; maximum, 8 years) were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Mean age was 59 years, and 68% were men. During long\u2010term follow\u2010up, 72 MACE occurred (overall crude cumulative incidence: 45% [95% confidence interval (CI): 37%\u201052%]). Lp(a) was associated with a higher 1\u2010year risk of MACE, with an adjusted hazard ratio (HR) of 3.1 (95% CI: 1.1\u20108.6) for the highest vs the lowest tertile. This association weakened and lost significance with long\u2010term follow\u2010up. IL\u201010 showed a tendency toward an association with MACE. The 1\u2010year HR was 2.1 (95% CI: 0.92\u20105.0). Long\u2010term follow\u2010up rendered a similar result. The association of CRP with MACE did not reach statistical significance at 1\u2010year follow\u2010up. However, CRP was associated with long\u2010term risk of MACE, with an HR of 1.9 (95% CI: 1.0\u20103.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>In this prospective study, preprocedural Lp(a) level was associated with short\u2010term prognosis after PCI. The preprocedural CRP level was associated with long\u2010term prognosis after PCI. <jats:italic>Clin. Cardiol.<\/jats:italic> 2012 DOI: 10.1002\/clc.21988<\/jats:p><jats:p>The authors have no funding, financial relationships, or conflicts of interest to disclose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.21988","type":"journal-article","created":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T13:31:33Z","timestamp":1333978293000},"page":"482-489","source":"Crossref","is-referenced-by-count":35,"title":["Lipoprotein(a), Interleukin\u201010, C\u2010Reactive Protein, and 8\u2010Year Outcome After Percutaneous Coronary Intervention"],"prefix":"10.1002","volume":"35","author":[{"given":"Isabella","family":"Kardys","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit M.","family":"Oemrawsingh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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