{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:05:57Z","timestamp":1757703957280},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T00:00:00Z","timestamp":1339718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>We examined the impact of non\u2013ST\u2010segment elevation acute coronary syndrome (NSTE\u2010ACS) on clinical outcomes in patients with bifurcation lesions treated with drug\u2010eluting stents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis:<\/jats:title><jats:p>We hypothesized that NSTE\u2010ACS would be attributable to the increased risk of major adverse cardiac events (MACE) in bifurcation percutaneous coronary intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We enrolled 1668 patients, using data from a multicenter real\u2010world bifurcation registry. The primary objective was to compare the 2\u2010year cumulative risk of MACE in patients with NSTE\u2010ACS to those with stable angina. Major adverse cardiac events were defined as the composite endpoint of cardiac death, myocardial infarction (MI), and target\u2010lesion revascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Non\u2013ST\u2010segment elevation acute coronary syndrome was seen in 969 (58.1%) patients and stable angina in 699. Major adverse cardiac events occurred in 7.3% of NSTE\u2010ACS patients and in 5.2% with stable angina (<jats:italic>P<\/jats:italic> = 0.042). However, cardiac death, MI, and target\u2010lesion revascularization were similar between the 2 groups. We stratified patients with NSTE\u2010ACS into those with non\u2013ST\u2010segment elevation MI and those with unstable angina. Cumulative risks of 2\u2010year MACEs were 7.0% in non\u2013ST\u2010segment elevation MI patients and 7.5% in unstable angina patients (<jats:italic>P<\/jats:italic> = 0.87). In the NSTE\u2010ACS cohort, the baseline lesion length in the side branch (adjusted hazard ratio [HR]: 1.04, 95% confidence interval [CI]: 1.01\u20101.07, <jats:italic>P<\/jats:italic> = 0.022), paclitaxel\u2010eluting stents in the main vessel (adjusted HR: 2.02, 95% CI: 1.21\u20103.40, <jats:italic>P<\/jats:italic> = 0.008), and final kissing ballooning (adjusted HR: 1.88, 95% CI: 1.10\u20103.21, <jats:italic>P<\/jats:italic> = 0.021) were independent predictors of MACE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Compared with stable angina patients, the NSTE\u2010ACS patients who underwent bifurcation percutaneous coronary intervention had an increased risk of MACE during the 2\u2010year follow\u2010up. <jats:italic>Clin. Cardiol.<\/jats:italic> 2012 doi: 10.1002\/clc.22020<\/jats:p><jats:p>Drs Pil Sang Song and Dong Ryeol Ryu contributed equally to this work. Coronary Bifurcation Stenting (COBIS) Registry in South Korea, US Department of Health and Human Services, US National Institutes of Health, ClinicalTrials.gov no. NCT00851526.<\/jats:p><jats:p>This work was supported by the Korean Society of Interventional Cardiology, Seoul, South Korea. The authors have no other funding, financial relationships, or conflicts of interest to disclose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22020","type":"journal-article","created":{"date-parts":[[2012,6,16]],"date-time":"2012-06-16T03:54:03Z","timestamp":1339818843000},"page":"610-618","source":"Crossref","is-referenced-by-count":12,"title":["Impact of Acute Coronary Syndrome Classification and Procedural Technique on Clinical Outcomes in Patients With Coronary Bifurcation Lesions Treated With Drug\u2010Eluting Stents"],"prefix":"10.1002","volume":"35","author":[{"given":"Pil","family":"Sang Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Ryeol Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Hyuk","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Hoon","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Bin","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo\u2010Yong","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Bae","family":"Seung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Jung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon\u2010Cheol","family":"Gwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0352"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1157\/13084649"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92619-Q"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001133420207"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn321"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/suq020"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.032"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.808402"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.11.083"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300322"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1885-5857(08)60253-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.966879"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22020","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T15:55:21Z","timestamp":1700582121000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,15]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1002\/clc.22020"],"URL":"https:\/\/doi.org\/10.1002\/clc.22020","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,15]]}}}