{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:27:40Z","timestamp":1792290460960,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T00:00:00Z","timestamp":1343606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>To investigate the clinical features of cardiac involvement in polymyositis (PM) or dermatomyositis (DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis:<\/jats:title><jats:p>More attention will be focused on the heart in PM\/DM as we would have wished, which contribute to improve the prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>All articles published in English were retrieved by searching MEDLINE via PubMed (1975\u20132011). After selecting eligible articles according to the predefined inclusion and exclusion criteria, a systemic review was carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A total of 26 articles were included in this study, which included 1530 patients. The incidence of cardiac involvement was 9% to 72%. Heart failure was the most frequent (32% to 77%) clinical symptom. Among the abnormal electrocardiogram and ultrasonic cardiogram, the incidence of conduction abnormalities, left ventricular diastolic dysfunction, and hyperkinetic left ventricular contraction were 25% to 38.5%, 42%, and 6% to 12%, respectively. The pathologic findings revealed myocardial inflammation, degenerative changes and necrosis similar to that in skeletal muscles. Cardiac manifestations of some patients improved after glucocorticoid and immunosuppressant treatment. Thirty\u2010seven patients (46.3%) died as a direct result of heart disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Heart abnormalities are frequent in patients with PM\/DM, most of which were subclinical. The efficacy of glucocorticoids and immunosuppressants is uncertain. Cardiac involvement is a common cause of death. <jats:italic>Clin. Cardiol.<\/jats:italic> 2012 doi: 10.1002\/clc.22026<\/jats:p><jats:p>The authors have no funding, financial relationships, or conflicts of interest to disclose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22026","type":"journal-article","created":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T14:56:21Z","timestamp":1343660181000},"page":"685-691","source":"Crossref","is-referenced-by-count":66,"title":["Cardiac Involvement in Adult Polymyositis or Dermatomyositis: A Systematic Review"],"prefix":"10.1002","volume":"35","author":[{"given":"Zhang","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Guo\u2010chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,30]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"805","article-title":"Dermatomyostitis.","author":"Oppenheim HZ.","year":"1899","journal-title":"Berl klin Wochenschrift."},{"key":"e_1_2_7_3_2","first-page":"373","article-title":"Cardiac manifestations in dermato\u2010polymyositis.","volume":"14","author":"Gonzalez\u2010Lopez L","year":"1996","journal-title":"Clin Exp Rheumatol."},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960161110"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197707000-00001"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel311"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000109755.65914.5e"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(86)90014-4"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780221007"},{"key":"e_1_2_7_10_2","first-page":"249","article-title":"Progognostic factors in polymyositis\/dermatomyosits.","volume":"28","author":"Benenbassat J","year":"1985","journal-title":"Arthritis Rheum."},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-94-1-41"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1984.04400020097015"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90408-8"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.57.2.176"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331979104201010"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(78)90871-8"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.038679"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01731845"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314509"},{"key":"e_1_2_7_20_2","first-page":"459","article-title":"Myocardial involvement in polymyositis.","volume":"10","author":"Strongwater SL","year":"1983","journal-title":"J Rheumatol."},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/AC.66.2.2071246"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.2.352"},{"key":"e_1_2_7_23_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0307-742X(21)00488-4","article-title":"Inflammatory disorders of muscle. 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