{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:39:12Z","timestamp":1786977552976,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T00:00:00Z","timestamp":1344470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Prior studies suggest that the incidence of ventricular arrhythmias is high in patients with Fabry cardiomyopathy. This study evaluated the incidence of significant arrhythmias in a series of patients with Fabry cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis:<\/jats:title>\n                    <jats:p>Arrhythmias are important causes of morbidity and mortality in Fabry Cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study was a retrospective chart review of 19 patients with known Fabry cardiomyopathy. Device interrogation reports were reviewed for those who had implantable devices. Electrocardiogram, Holter monitor, and event monitors were reviewed in those who did not have implantable devices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Eighteen of nineteen patients were on enzyme replacement therapy (ERT). Nine (47%) out of 19 patients had implantable devices. Implant indications included symptomatic bradycardia, nonsustained ventricular tachycardia, conduction abnormalities, palpitations, and syncope. Mean follow\u2010up in the patients with devices was 50 \u00b1 23 months. Two patients received implantable cardioverter\u2010defibrillator (ICD) shocks, 1 of which was inappropriate for atrial fibrillation. Patients were paced in the atrium 71% \u00b1 37% of the time and paced in the ventricle 49% \u00b1 52% of the time. Four patients with devices were paced more than 95% of the time. Patients with an ICD had lower heart rates prior to ICD implant than the group that did not have devices (60 \u00b1 10 vs 78 \u00b1 16,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.03). Of the patients without devices, only 1 had sudden cardiac death. Patients with implanted devices had higher left ventricular (LV) mass indices compared to patients without implanted devices (136 \u00b1 40 g\/m\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib2\">2<\/jats:ext-link>\n                      vs 93 \u00b1 19 g\/m\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib2\">2<\/jats:ext-link>\n                      ,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.008).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Significant ventricular arrhythmias are uncommon in patients with Fabry cardiomyopathy on ERT, but utilization of pacing is high. Sudden cardiac death in Fabry cardiomyopathy may be related to bradycardia.<\/jats:p>\n                    <jats:p>The authors have no funding, financial relationships, or conflicts of interest to disclose.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.22047","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T10:03:42Z","timestamp":1344506622000},"page":"738-740","source":"Crossref","is-referenced-by-count":47,"title":["Arrhythmias in Fabry Cardiomyopathy"],"prefix":"10.1002","volume":"35","author":[{"given":"Deepak","family":"Acharya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Neal Kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Warnock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vance J.","family":"Plumb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Tallaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.01.035"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-090910-085119"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.3.249"},{"key":"e_1_2_6_5_2","first-page":"1004","article-title":"Fabry disease\u2014a diagnostic and therapeutic challenge [in Norwegian].","volume":"125","author":"Houge G","year":"2005","journal-title":"Tidsskr Nor Laegeforen."},{"key":"e_1_2_6_6_2","volume-title":"Fabry Disease: Perspectives from 5 Years of FOS.","author":"Mehta A","year":"2006"},{"key":"e_1_2_6_7_2","volume-title":"Fabry Disease: Perspectives from 5 Years of FOS.","author":"Linhart A.","year":"2006"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2005.03191.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012428009627"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.018"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.01.020"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.723387"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2005.00241.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.11.080"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.05.033"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.68.9.323"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur267"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2007.12.001"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90771-X"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.21.2743"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107053450102"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107053450104"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000091253.71282.04"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2004.00284.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.104026"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0b013e31818adc50"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm153"},{"key":"e_1_2_6_28_2","unstructured":"USFoodand Drug Administration.http:\/\/www.fda.gov\/downloads\/Drugs\/DrugSafety\/DrugShortages\/UCM187056.pdf. 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