{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T01:12:15Z","timestamp":1768785135397,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:00:00Z","timestamp":1363219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our goal was to define the prevalence of radiation\u2010induced valvular heart (<jats:styled-content style=\"fixed-case\">RIVD<\/jats:styled-content>) disease among patients undergoing cardiac valve surgery in a community\u2010based, regional academic medical center.  Mediastinal radiation is a treatment modality for various hematologic and solid malignancies; however, long\u2010term cardiac complications, including radiation\u2010induced valvular heart disease, can occur years after the radiation treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Mediastinal radiation exposure is an independent risk factor for valvular heart disease often necessitating valve replacement in patients without other risk factors for valve disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 1, 1998 and September 1, 2007, we retrospectively analyzed our institution's cardiac surgical database over a 10 year period and identified 189 consecutive patients \u2264 50 years of age who underwent valve surgery.  Using case\u2010control matching, we assessed the prevalence of mediastinal radiation among these young patients with valve disease necessitating surgery and to their matched controls from all patients admitted to the hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine individuals (4.8%) were identified as having received previous mediastinal radiation, significantly increased from controls (p&lt;0.0001), and 8 of whom had surgical or pathologic findings consistent with radiation damage.  Compared with a matched case\u2010control population, individuals who had severe valve disease and underwent valve replacement had a markedly increased prevalence of prior mediastinal radiation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, cardiologists must remain aware of the potential long term valvular complications in patients treated with mediastinal radiation.  Increased surveillance for <jats:styled-content style=\"fixed-case\">RIVD<\/jats:styled-content> may be considered in the decades following radiation therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22106","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T03:47:35Z","timestamp":1363319255000},"page":"217-221","source":"Crossref","is-referenced-by-count":17,"title":["Frequency of Severe Valvular Disease Caused by Mediastinal Radiation Among Patients Undergoing Valve Surgery in a Community\u2010Based, Regional Academic Medical Center"],"prefix":"10.1002","volume":"36","author":[{"given":"Kevin A.","family":"Copeland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay 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