{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:53:32Z","timestamp":1788501212237,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T00:00:00Z","timestamp":1368403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this prospective survey was to describe the demographics, stroke risk profile, and the guideline adherence of antithrombotic treatment in a Danish primary care population of patients with nonvalvular atrial fibrillation (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that a significant proportion of patients with nonvalvular AF do not receive guideline\u2010adherent antithrombotic treatment in primary care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional survey of antithrombotic treatment using data of AF patients from general practices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010four general practitioners enrolled 1743 patients with a mean age of 74.8\u2009\u00b1\u200911.2 years. The mean <jats:styled-content style=\"fixed-case\">CHADS<jats:sub>2<\/jats:sub><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc<\/jats:styled-content> scores were 1.9\u2009\u00b1\u20091.3 and 3.5\u2009\u00b1\u20091.8, respectively. Of the patients, 12.4% and 4.04%, respectively, were at truly low risk, with a <jats:styled-content style=\"fixed-case\">CHADS<jats:sub>2<\/jats:sub><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc<\/jats:styled-content> score 0 (<jats:italic>P<\/jats:italic> &lt; 0.001). A score of 1 was seen in 28.0% vs 9.0% (<jats:italic>P<\/jats:italic> &lt; 0.001) of the patients. Of all patients, 66.3% were treated with oral anticoagulants, 18.7% with antiplatelet drugs only, and 15% received no antithrombotic therapy. Based on the <jats:styled-content style=\"fixed-case\">CHADS<jats:sub>2<\/jats:sub><\/jats:styled-content> score, 75.7% of the patients were treated in adherence with the guidelines, 16% were undertreated, and 8.4% overtreated. The corresponding numbers for the <jats:styled-content style=\"fixed-case\">CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc<\/jats:styled-content> score were 75.4%, 22.7%, and 1.8%, respectively. The differences in guideline adherence applying the 2 scores were significant (<jats:italic>P<\/jats:italic> &lt; 0.001). Of patients receiving no antithrombotic therapy, 64.1% were treated in adherence to the guidelines according to the <jats:styled-content style=\"fixed-case\">CHADS<jats:sub>2<\/jats:sub><\/jats:styled-content> score. Applying the <jats:styled-content style=\"fixed-case\">CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc<\/jats:styled-content> score, this proportion was only 53.4%. Antiplatelet drug treatment was in adherence to the guidelines (<jats:styled-content style=\"fixed-case\">CHADS<jats:sub>2<\/jats:sub><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc<\/jats:styled-content> score of 1) in only 31% and 12% of the patients, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antithrombotic treatment of <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> patients is in general well performed in primary care in Denmark. Further improvements may be achieved by thorough stroke risk stratification on the basis of current evidence\u2010based guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22133","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T14:08:40Z","timestamp":1368454120000},"page":"427-432","source":"Crossref","is-referenced-by-count":23,"title":["Guideline Adherence of Antithrombotic Treatment Initiated by General Practitioners in Patients With Nonvalvular Atrial Fibrillation: A Danish Survey"],"prefix":"10.1002","volume":"36","author":[{"given":"Axel","family":"Brandes","sequence":"first","affiliation":[{"name":"Department of Cardiology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel","family":"Overgaard","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liane","family":"Plauborg","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dehlendorff","sequence":"additional","affiliation":[{"name":"DTU Data Analysis Technical University of Denmark  Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frede","family":"Lyck","sequence":"additional","affiliation":[{"name":"General Practice  Solr\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Peulicke","sequence":"additional","affiliation":[{"name":"General Practice  Esperg\u00e6rde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren Vinther","family":"Poulsen","sequence":"additional","affiliation":[{"name":"DTU Data Analysis Technical University of Denmark  Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Husted","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Unit West  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01236-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1076-7460.2005.02278.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000068743"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000166053.83476.4a"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-12-200706190-00007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euq350"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.20.2685"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1994.00420130036007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/archinte.1997.00440320143013","article-title":"The efficacy of aspirin in patients with atrial fibrillation. 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