{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:24:22Z","timestamp":1788992662227,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:00:00Z","timestamp":1369785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Widespread use of echocardiography has made earlier diagnosis of patent ductus arteriosus (PDA<\/jats:styled-content>) possible, but pharmacological or surgical intervention is highly variable. Herein, we investigate the prevalence of PDA<\/jats:styled-content> and its management in a routine care system.<\/jats:p><\/jats:sec>Methods<\/jats:title>A 15\u2010year retrospective dataset (1996\u20132010) was analyzed. Selection criteria included age \u226417\u2009years, enrollees in South Carolina State Medicaid, and diagnosed as having PDA<\/jats:styled-content> on 1 or more service visits to a pediatrician or pediatric cardiologist.<\/jats:p><\/jats:sec>Results<\/jats:title>The 15\u2010year treated prevalence rate of PDA<\/jats:styled-content> was 0.25\/1000 pediatric cases of congenital heart disease (CHD<\/jats:styled-content>). PDA<\/jats:styled-content> was more prevalent in non\u2010African American patients (adjusted odds ratio [aOR<\/jats:styled-content>]: 1.12), but not in females after controlling for all other CHDs<\/jats:styled-content> diagnosed in the cohort. Associated CHDs<\/jats:styled-content> were present in 57.6% of the cases, primarily atrial or ventricular septal defects, and fewer patients (5.5%) developed pulmonary hypertension. Of 3627 PDA<\/jats:styled-content> cases examined, 70.0% received no medications or PDA<\/jats:styled-content> repair. Therapeutic ibuprofen was used for closure in 24.4% of the cases, and a PDA<\/jats:styled-content> repair was performed in 7.8%. Younger children (aOR<\/jats:styled-content>: 0.82), those who received an atrial septal defect closure (aOR<\/jats:styled-content>: 5.18), and those who were treated with digoxin (aOR<\/jats:styled-content>: 1.86) or with diuretics or preload\/afterload reducing agents (ie, calcium channel blockers or angiotensin\u2010converting enzyme inhibitors) (aOR<\/jats:styled-content>: 5.72)\u2009were significantly more likely to have a PDA<\/jats:styled-content> repair procedure.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The majority of diagnosed PDA<\/jats:styled-content> cases did not require pharmacological or surgical intervention. Those receiving pharmacological or surgical intervention were treated conservatively in relation to the presence of distress symptoms or concomitant CHDs<\/jats:styled-content> requiring intervention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22150","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T14:03:55Z","timestamp":1369836235000},"page":"502-506","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence and Management of Patent Ductus Arteriosus in a Pediatric Medicaid Cohort"],"prefix":"10.1002","volume":"36","author":[{"given":"Avnish","family":"Tripathi","sequence":"first","affiliation":[{"name":"Department Medicine University of Mississippi School of Medicine Jackson Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George B.","family":"Black","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry and Behavioral Science University of South Carolina School of Medicine Columbia South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Moon Mark","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of South Carolina Arnold School of Public Health Columbia South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette M.","family":"Jerrell","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry and Behavioral Science University of South Carolina School of Medicine Columbia South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,29]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"KeaneJF FylerDC.Patent ductus arteriosus. In:KeaneJF ed.Nadas' Pediatric Cardiology. 2nd ed. 2006. http:\/\/www.mdconsult.com\/books\/page.do?eid\u2009=\u20094\u2010u1.0\u2010B978\u20101\u20104160\u20102390\u20106..50040\u20104&isbn\u2009=\u2009978\u20101\u20104160\u20102390\u20106&uniqId\u2009=\u2009406511368\u20103#4\u2010u1.0\u2010B978\u20101\u20104160\u20102390\u20106..50040\u20104\u2010\u2010cesec1. Accessed November 28 2012."},{"key":"e_1_2_6_3_1","unstructured":"BernsteinD.Patent ductus arteriosus. In: Kleigman RM Stanton B St. Geme J et al eds.Nelson Textbook of Pediatrics. 19th ed. 2011. http:\/\/www.mdconsult.com\/books\/page.do?eid\u2009=\u20094\u2010u1.0\u2010B978\u20101\u20104377\u20100755\u20107..00420\u20106\u2010\u2010sc0025&isbn\u2009=\u2009978\u20101\u20104377\u20100755\u20107&uniqId\u2009=\u2009406511368\u20103#4\u2010u1.0\u2010B978\u20101\u20104377\u20100755\u20107..00420\u20106\u2010\u2010sc0025. 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Table D1: children under 18 and their designated parents; Table D2: children under 18 and their designated parents\u2014characteristics of families (including region). http:\/\/www.census.gov\/hhes\/socdemo\/children\/data\/sipp\/well2009\/tables.html. Accessed January 30 2013."},{"key":"e_1_2_6_13_1","unstructured":"US Census Bureau Web site. Profile of general population and housing characteristics: 2010 census summary file 2. http:\/\/factfinder2.census.gov\/faces\/tableservices\/jsf\/pages\/productview.xhtml?pid\u2009=\u2009DEC_10_SF2_SF2DP1&prodType\u2009=\u2009table. 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