{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:14:16Z","timestamp":1784229256795,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T00:00:00Z","timestamp":1377561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective was to evaluate coronary blood flow (<jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>) in patients with systemic arterial hypertension (<jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>) and to compare it with <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> in patients with aortic regurgitation (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>). A systematic literature search was conducted using the reference terms \u201ccoronary blood flow\u201d and either \u201caortic regurgitation\u201d or \u201chypertension.\u201d The selection criteria included <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> measurement in a concomitant control group, except studies evaluating <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> with aortic\u2010valve replacement surgery. Twenty\u2010two studies met the inclusion criteria. There were 318 persons with <jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>, with 185 controls; and 102 persons with <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>, with 144 controls. Despite an overall increase in <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> per gram of left ventricular mass was significantly (<jats:italic>P<\/jats:italic> &lt; 0.0001) reduced. In contrast, <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> per gram of left ventricular mass was significantly (<jats:italic>P<\/jats:italic> = 0.004) increased in <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>. Aortic regurgitation was associated with a significant (<jats:italic>P<\/jats:italic> &lt; 0.0001) increase in <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> during systole and away from diastole, in contrast to persons with <jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>. Aortic\u2010valve replacement reversed the increase in systolic <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>. These data suggest that patients with <jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content> are more vulnerable than patients with <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> to lower diastolic blood pressure (<jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content>), because resting <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> is compromised in <jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content>. Furthermore, patients with <jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content> may not compensate for <jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content> reductions by shifting <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> to systole, such as can occur with the low <jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>. Lower <jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> cannot be used to justify treating patients with <jats:styled-content style=\"fixed-case\">HTN<\/jats:styled-content> to similar <jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content> because of the dramatic differences in <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> between the 2 conditions.<\/jats:p>","DOI":"10.1002\/clc.22194","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T13:48:33Z","timestamp":1377611313000},"page":"728-736","source":"Crossref","is-referenced-by-count":5,"title":["Differences in Coronary Blood Flow in Aortic Regurgitation and Systemic Arterial Hypertension Have Implications for Diastolic Blood Pressure Targets: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"36","author":[{"given":"Simon 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