{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:07:15Z","timestamp":1782515235383,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T00:00:00Z","timestamp":1379376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac resynchronization therapy (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>) is an established therapy for patients with chronic heart failure (<jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>) and a broad <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> complex. Gender\u2010related safety and efficacy data are necessary for informed patient decision\u2010making for female patients with <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>. The aim of the study was to assess the effects of gender on the outcome of <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> in highly symptomatic heart failure patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Gender may have an effect on the outcome of heart failure patients undergoing cardiac resynchronisation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study analyzed the 2\u2010year follow\u2010up of 393 New York Heart Association (<jats:styled-content style=\"fixed-case\">NYHA<\/jats:styled-content>) class <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> patients with a class I <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> indication enrolled in the Management of Atrial Fibrillation Suppression in <jats:styled-content style=\"fixed-case\">AF\u2010HF<\/jats:styled-content> Comorbidity Therapy (<jats:styled-content style=\"fixed-case\">MASCOT<\/jats:styled-content>) study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In female patients (n = 82), compared with male patients (n = 311), <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content> was more often due to dilated cardiomyopathy (74% vs 44%, respectively; <jats:italic>P<\/jats:italic> &lt; 0.0001). Females also had a more impaired quality\u2010of\u2010life score and a smaller left ventricular end\u2010diastolic diameter (<jats:styled-content style=\"fixed-case\">LVEDD<\/jats:styled-content>). Women were less likely than men to have received a <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> defibrillator (35% vs 61%, respectively; <jats:italic>P<\/jats:italic> &lt; 0.0001). After 2 years, the devices had delivered more biventricular pacing in women than in men (96% \u00b1 13% vs 94% \u00b1 13%, respectively; <jats:italic>P<\/jats:italic> &lt; 0.0004). Women had a greater reduction in <jats:styled-content style=\"fixed-case\">LVEDD<\/jats:styled-content> than did men (\u22128.2 mm \u00b1 11.1 mm vs \u22121.1 mm \u00b1 22.1 mm, respectively; <jats:italic>P<\/jats:italic> &lt; 0.02). Both genders improved similarly in <jats:styled-content style=\"fixed-case\">NYHA<\/jats:styled-content> functional class. Women reported greater improvement than men in quality\u2010of\u2010life score (\u221221.1 \u00b1 26.5 vs \u221216.2 \u00b1 22.1, respectively; <jats:italic>P<\/jats:italic> &lt; 0.0001). After adjustment for cardiovascular history, women had lower all\u2010cause mortality (<jats:italic>P<\/jats:italic> = 0.0007), less cardiac death (<jats:italic>P<\/jats:italic> = 0.04), and fewer hospitalizations for worsening heart failure (<jats:italic>P<\/jats:italic> = 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Females exhibited a better response to <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> than did males. Because females have such impressive benefits from <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>, improved screening and advocacy for <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> implantation in women should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22203","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T15:12:11Z","timestamp":1381245131000},"page":"683-690","source":"Crossref","is-referenced-by-count":26,"title":["Gender\u2010Related Safety and Efficacy of Cardiac Resynchronization Therapy"],"prefix":"10.1002","volume":"36","author":[{"given":"Andreas","family":"Schuchert","sequence":"first","affiliation":[{"name":"Medical Clinic Friedrich\u2010Ebert Hospital Neum\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Muto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Loreto Mare Hospital Naples 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