{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:25:36Z","timestamp":1769275536867,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In addition to insulin\u2010sensitizing effects, adiponectin influences several mechanisms involved in pulmonary arterial hypertension (<jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content>) pathobiology. Insulin resistance has been associated with <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content>, and elevated adiponectin levels have been described in left heart failure (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>) as a response to the increased metabolic stress. No studies have been performed in right <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Compared to healthy controls, <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content> patients have a different plasma adipocytokine profile, higher insulin resistance, and higher inflammatory systemic activation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study was conducted in <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content> patients individually matched for sex, age, and body mass index. We characterized the clinical features, functional status (6\u2010minute walking test), and hemodynamic profile of cases (n = 25). We measured insulin resistance (homeostasis model assessment and high\u2010density lipoprotein\/triglycerides ratio), inflammatory systemic activation (high\u2010sensitivity C\u2010reactive protein), and plasma adipocytokine profile (adiponectin, leptin, visfatin, and resistin) in cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content> patients had significantly higher adiponectin levels than controls (12.4 \u00b1 6.9 vs 8.1 \u00b1 4.5 \u00b5g\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>; <jats:italic>P<\/jats:italic> &lt; 0.05) and higher high\u2010sensitivity C\u2010reactive protein (2.96 \u00b1 3.2 vs 1.08 \u00b1 1.1; <jats:italic>P<\/jats:italic> &lt; 0.05). No statistically significant differences were found in plasma levels of leptin, visfatin, and resistin between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adiponectin levels are increased in <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content> patients compared to controls. Further studies are needed to study the potential role of adiponectin as a <jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content> biomarker.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22210","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:41:24Z","timestamp":1381542084000},"page":"21-25","source":"Crossref","is-referenced-by-count":24,"title":["Adiponectin Levels Are Elevated in Patients With Pulmonary Arterial Hypertension"],"prefix":"10.1002","volume":"37","author":[{"given":"M\u00e1rio","family":"Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ab\u00edlio","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel J.","family":"Ferreira\u2010Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Cabral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Severo","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelino F.","family":"Leite\u2010Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago","family":"Henriques\u2010Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.05.066"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.847707"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20050182"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1937"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90599.2008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.198044"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.04.018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.663120"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0415OC"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.530972"},{"key":"e_1_2_7_12_1","unstructured":"Van BerendoncksAM GarnierA Ventura\u2010ClapierR et al. 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