{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T05:36:42Z","timestamp":1772861802081,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T00:00:00Z","timestamp":1381104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An acute\u2010phase response in patients with acute myocardial infarction could contribute to the development of anemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>An association may exist between symptom duration, hemoglobin (Hb) concentration and serum C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) values in patients presenting to an emergency department (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) with acute <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u2010segment elevation myocardial infarction (<jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on consecutive male <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content> patients who were admitted to our medical center's <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> from January 2008 to November 2012 and had presented within the first 12 hours after the onset of chest pain. Hemoglobin concentration and serum <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels were determined from blood samples taken prior to any drug or fluid administration. Analyses of variance were used to determine interactions between selected time\u2010to\u2010presentation cutoffs and admission Hb and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> concentrations. Patients with other reasons known to cause elevation of inflammatory markers, anemia, or bleeding diathesis were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population comprised 718 patients whose mean age was 61 \u00b1 12 years (range, 27\u201396 years). Blood was drawn for Hb and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> measurements directly upon admission. Patients who presented to the <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> within 3 hours of symptom onset had higher Hb concentrations (<jats:italic>P<\/jats:italic> = 0.048) and lower serum <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels (<jats:italic>P<\/jats:italic> &lt; 0.001) compared with those who presented after a longer interval from symptom onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Longer symptom duration is associated with a lower admission Hb level and an early rise in the <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> level of male patients with acute <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22215","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:04:53Z","timestamp":1381543493000},"page":"73-77","source":"Crossref","is-referenced-by-count":24,"title":["Lower Admission Hemoglobin Levels Are Associated With Longer Symptom Duration in Acute <scp>ST<\/scp>\u2010Elevation Myocardial 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