{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:16:56Z","timestamp":1760242616404},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T00:00:00Z","timestamp":1383091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Therapeutic hypothermia improves survival for selected patients who remain comatose after cardiac arrest. Hypothermia triggers changes in electrocardiographic (<jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content>) parameters; however, the association of these changes to in\u2010hospital mortality remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content> interval changes induced by therapeutic hypothermia are not associated with in\u2010hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively compared precooling <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> parameters to <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> parameters during hypothermia on all consecutive patients with available information who received hypothermia at our academic medical center between December 2006 and July 2012 (N\u2009=\u2009101; 24% women). Paired 2\u2010sample <jats:italic>t<\/jats:italic> test was used to compare precooling vs cooling <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> parameters. In\u2010hospital mortality related to <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> parameter changes was compared using the Pearson \u03c7<jats:sup>2<\/jats:sup> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Therapeutic hypothermia resulted in increases in <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">QTc<\/jats:styled-content> intervals and decreases in heart rate and <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> intervals (<jats:italic>P<\/jats:italic> for all &lt;0.02). During hospitalization, 45 of the 101 patients died. Survivors vs nonsurvivors did not differ in heart rate change (<jats:italic>P<\/jats:italic> = 0.74), <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> change (<jats:italic>P<\/jats:italic> = 0.57), <jats:styled-content style=\"fixed-case\">QRS<\/jats:styled-content> change (<jats:italic>P<\/jats:italic> = 0.09), or <jats:styled-content style=\"fixed-case\">QTc<\/jats:styled-content> change (<jats:italic>P<\/jats:italic> = 0.67). Comparing patients who had reduced <jats:styled-content style=\"fixed-case\">QTc<\/jats:styled-content> intervals with hypothermia to those who had prolonged <jats:styled-content style=\"fixed-case\">QTc<\/jats:styled-content> with hypothermia, 14 out of 30 died in the former group, whereas 31 out of 71 died in the latter group (46.7% vs 43.7%, odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>]: 1.13, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.48\u20102.66). Patients presenting with right bundle branch block (<jats:styled-content style=\"fixed-case\">RBBB<\/jats:styled-content>) had a higher risk of in\u2010hospital death compared to those without <jats:styled-content style=\"fixed-case\">RBBB<\/jats:styled-content> (72.2% vs 38.6%, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 4.14, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.35\u201012.73).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Therapeutic hypothermia prolonged <jats:styled-content style=\"fixed-case\">QTc<\/jats:styled-content> interval with no association to in\u2010hospital mortality. Presence of <jats:styled-content style=\"fixed-case\">RBBB<\/jats:styled-content> on initial presentation was related to increased mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22224","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T15:42:40Z","timestamp":1383147760000},"page":"97-102","source":"Crossref","is-referenced-by-count":17,"title":["Therapeutic Hypothermia\u2010Induced Electrocardiographic Changes and Relations to In\u2010hospital Mortality"],"prefix":"10.1002","volume":"37","author":[{"given":"David H.","family":"Lam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Dhingra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila M.","family":"Conley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan 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