{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:32:20Z","timestamp":1778049140782,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T00:00:00Z","timestamp":1388966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patent ductus arteriosus (<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>) remains a common congenital heart disease in pediatric patients, and the new trend of catheterization therapy is still associated with some potential risks and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Compared with surgical closure, the clinical effect of catheterization therapy in pediatric <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> patients requires meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic literature search of <jats:styled-content style=\"fixed-case\">PubMed<\/jats:styled-content>, Cochrane Library, Embase, Science Citation Index, Web of Science, and the Chinese Biomedicine literature database was conducted. Eligible studies included controlled trials of pediatric <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> patients receiving catheterization therapy vs surgical closure. Relative risks (<jats:styled-content style=\"fixed-case\">RRs<\/jats:styled-content>), standard mean differences, and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CIs<\/jats:styled-content>) were calculated and heterogeneity was assessed with the <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven studies with a total of 810 patients met the inclusion criteria. Catheterization therapy neither significantly increased the primary success rate (RR: 0.92, 95% CI: 0.82\u20101.03, <jats:italic>P<\/jats:italic> = 0.16) nor reduced the total postprocedure complications (RR: 0.74, 95% CI: 0.44\u20101.25, <jats:italic>P<\/jats:italic> = 0.26) and blood transfusion (RR: 1.10, 95% CI: 0.16\u20107.67, <jats:italic>P<\/jats:italic> = 0.93). Catheterization was associated with a statistically significant increase in residual shunts (RR: 5.19, 95% CI: 1.41\u201019.20, <jats:italic>P<\/jats:italic> = 0.01) and reduction in length of hospital stay (standard mean difference: \u22121.66, 95% CI: \u22122.65 to \u22120.67, <jats:italic>P<\/jats:italic> = 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Catheterization therapy in pediatric PDA patients did not show a significant advantage in primary success rate, total complications, or blood transfusion, but it was associated with increase in residual shunts and reduction in length of hospital stay.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22238","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T15:53:05Z","timestamp":1389023585000},"page":"188-194","source":"Crossref","is-referenced-by-count":14,"title":["Catheterization Therapy vs Surgical Closure in Pediatric Patients With Patent Ductus Arteriosus: A 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