{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:50:13Z","timestamp":1786369813085,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T00:00:00Z","timestamp":1391040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Novartis-Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Most evidence regarding the efficacy and safety of the antithrombotic regimens for patients with atrial fibrillation (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) undergoing percutaneous coronary intervention with stent (<jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>\u2010S) derives from small, single\u2010center, retrospective datasets. To obtain further data on this issue, we carried out the prospective, multicenter, observational Management of patients with Atrial Fibrillation undergoing Coronary Artery Stenting (<jats:styled-content style=\"fixed-case\">AFCAS<\/jats:styled-content>) registry (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/Clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link> identifier <jats:styled-content style=\"fixed-case\">NCT00596570<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesize that the antithrombotic treatment of AF patients undergoing PCI\u2010S is variable and the clinical outcome may vary according to the different regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> patients undergoing <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>\u2010S at 17 European institutions were included and followed for 1 year. Outcome measures included: (1) major adverse cardiac\/cerebrovascular events (<jats:styled-content style=\"fixed-case\">MACCE<\/jats:styled-content>), including all\u2010cause death, myocardial infarction, repeat revascularization, stent thrombosis, or stroke\/transient ischemic attack, and (2) bleeding, and were compared according to the antithrombotic regimen adopted. A propensity\u2010score analysis was carried out to adjust for baseline and procedural differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the 975 patients enrolled, 914 were included in the final analysis. The mean <jats:styled-content style=\"fixed-case\">CHADS<jats:sub>2<\/jats:sub><\/jats:styled-content> score was 2.2\u2009\u00b1\u20091.2, and 71% of patients had a <jats:styled-content style=\"fixed-case\">CHADS<jats:sub>2<\/jats:sub><\/jats:styled-content> score \u22652. Triple therapy (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>) of vitamin K antagonist (<jats:styled-content style=\"fixed-case\">VKA<\/jats:styled-content>), aspirin, and clopidogrel was prescribed to 74% of patients, dual antiplatelet therapy to 18%, and <jats:styled-content style=\"fixed-case\">VKA<\/jats:styled-content> plus clopidogrel to 8%. At 1\u2010year follow\u2010up, no significant differences were found in the occurrence of <jats:styled-content style=\"fixed-case\">MACCE<\/jats:styled-content> and bleeding among the 3 antithrombotic regimens, even when adjusted for propensity score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this large, real\u2010world population of <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> patients undergoing <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>\u2010S, <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> was the antithrombotic regimen most frequently prescribed. Although several limitations need to be acknowledged, in our study the 1\u2010year efficacy and safety of <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>, dual antiplatelet therapy, and <jats:styled-content style=\"fixed-case\">VKA<\/jats:styled-content> plus clopidogrel was comparable.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22254","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T15:41:50Z","timestamp":1391096510000},"page":"357-364","source":"Crossref","is-referenced-by-count":76,"title":["One\u2010Year Outcome of Patients With Atrial Fibrillation Undergoing Coronary Artery Stenting: An Analysis of the <scp>AFCAS<\/scp> Registry"],"prefix":"10.1002","volume":"37","author":[{"given":"Andrea","family":"Rubboli","sequence":"first","affiliation":[{"name":"Division of Cardiology Laboratory of Interventional Cardiology  Ospedale Maggiore Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Schlitt","sequence":"additional","affiliation":[{"name":"Department of Medicine III Martin Luther\u2010University  Halle Germany"},{"name":"Department of Cardiology Paracelsus Harz\u2010Clinic  Bad Suderode Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Kiviniemi","sequence":"additional","affiliation":[{"name":"Heart Center Turku University Hospital and University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Biancari","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasi P.","family":"Karjalainen","sequence":"additional","affiliation":[{"name":"Heart Center Satakunta Central Hospital  Pori Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e8","family":"Valencia","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Laine","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology, University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulus","family":"Kirchhof","sequence":"additional","affiliation":[{"name":"University of Birmingham Centre for Cardiovascular Sciences City Hospital  Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Niemel\u00e4","sequence":"additional","affiliation":[{"name":"Division of Cardiology University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saila","family":"Vikman","sequence":"additional","affiliation":[{"name":"Heart Center University Hospital  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"University of Birmingham Centre for Cardiovascular Sciences City Hospital  Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. E. Juhani","family":"Airaksinen","sequence":"additional","affiliation":[{"name":"Heart Center Turku University Hospital and University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the AFCAS Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-08-0580"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-04-0262"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq278"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61751-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.271"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.114967"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.029"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62177-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1160\/TH08-05-0334","article-title":"Pro: Antithrombotic therapy with warfarin, aspirin and clopidogrel is the recommended regime in anticoagulated patients who present with an acute coronary syndrome and\/or undergo percutaneous coronary interventions","volume":"100","author":"Rubboli A","year":"2008","journal-title":"Thromb Haemost."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.187397"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25064"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22167"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht461"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-09-0880"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-3083"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.11.019"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22254","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:58:51Z","timestamp":1696323531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,30]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1002\/clc.22254"],"URL":"https:\/\/doi.org\/10.1002\/clc.22254","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,30]]}}}