{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:17:51Z","timestamp":1773314271890,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The Randomized Endo\u2010vein Graft Prospective (<jats:styled-content style=\"fixed-case\">REGROUP<\/jats:styled-content>) trial (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials\">ClinicalTrials.gov<\/jats:ext-link>\u00a0<jats:styled-content style=\"fixed-case\">NCT01850082<\/jats:styled-content>) is a randomized, intent\u2010to\u2010treat, 2\u2010arm, parallel\u2010design, multicenter study funded by the Cooperative Studies Program (<jats:styled-content style=\"fixed-case\">CSP<\/jats:styled-content> No. 588) of the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> Department of Veterans Affairs. Cardiac surgeons at 16 Veterans Affairs (<jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content>) medical centers with technical expertise in performing both endoscopic vein harvesting (<jats:styled-content style=\"fixed-case\">EVH<\/jats:styled-content>) and open vein harvesting (<jats:styled-content style=\"fixed-case\">OVH<\/jats:styled-content>) were recruited as the <jats:styled-content style=\"fixed-case\">REGROUP<\/jats:styled-content> surgeon participants. Subjects requiring elective or urgent coronary artery bypass grafting using cardiopulmonary bypass with use of \u22651 saphenous vein graft will be screened for enrollment using pre\u2010established inclusion\/exclusion criteria. Enrolled subjects (planned N\u2009=\u20091150) will be randomized to 1 of the 2 arms (<jats:styled-content style=\"fixed-case\">EVH<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">OVH<\/jats:styled-content>) after an experienced vein harvester has been assigned. The primary outcomes measure is the rate of major adverse cardiac events (<jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>), including death, myocardial infarction, or revascularization. Subject assessments will be performed at multiple times, including at baseline, intraoperatively, postoperatively, and at discharge (or 30\u2009days after surgery, if still hospitalized). Assessment of leg\u2010wound complications will be completed at 6\u2009weeks after surgery. Telephone follow\u2010ups will occur at 3\u2010month intervals after surgery until the participating sites are decommissioned after the trial's completion (approximately 4.5\u2009years after the full study startup). To assess long\u2010term outcomes, centralized follow\u2010up of <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content> for 2 additional years will be centrally performed using <jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content> clinical and administrative databases. The primary <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content> outcome will be compared between the 2 arms, <jats:styled-content style=\"fixed-case\">EVH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OVH<\/jats:styled-content>, at the end of the trial duration.<\/jats:p>","DOI":"10.1002\/clc.22267","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T22:52:40Z","timestamp":1394837560000},"page":"325-330","source":"Crossref","is-referenced-by-count":16,"title":["Choice of Vein\u2010Harvest Technique for Coronary Artery Bypass Grafting: Rationale and Design of the <scp>REGROUP<\/scp> Trial"],"prefix":"10.1002","volume":"37","author":[{"given":"Marco A.","family":"Zenati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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