{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T22:35:58Z","timestamp":1725402958487},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a paucity of data on the temporal trends of cardiovascular risk factors in patients undergoing percutaneous coronary intervention (<jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>). We investigated the secular trends of risk profiles of patients undergoing <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content> without prior history of cardiovascular disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>CVD risk factors are changed over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This time\u2010trend analysis from 1994 to 2010 was performed within the Mayo Clinic <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content> Registry. Outcome measures were prevalence of <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> risk factors, including the Framingham risk score (<jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content>), at the time of admission for <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During this period, 12,055 patients without a history of <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> (mean age, 65.0\u2009\u00b1\u200912.4\u2009years, 67% male) underwent <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content> at the Mayo Clinic. Age distribution slightly shifted toward older age (<jats:italic>P<\/jats:italic> for trend &lt;0.05), but sex did not change over time. Despite a higher prevalence of hypertension, hypercholesterolemia, and diabetes mellitus over time, actual blood pressure and lipid profiles improved (<jats:italic>P<\/jats:italic> for trend &lt;0.001). Over time, <jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content> and 10\u2010year <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> risk improved significantly (7.3\u2009\u00b1\u20093.2 to 6.5\u2009\u00b1\u20093.3, <jats:italic>P<\/jats:italic> for trend &lt;0.001; and 11.0 to 9.0, <jats:italic>P<\/jats:italic> for trend &lt;0.001, respectively). Body mass index, not included in the <jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content>, increased significantly (29.0\u2009\u00b1\u20095.2 to 30.1\u2009\u00b1\u20096.2\u2009kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic> for trend &lt;0.001), whereas smoking prevalence did not change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current study demonstrates that although traditional <jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content> and its associated predicted 10\u2010year cardiovascular risk declined over time, the prevalence of risk factors increased in patients undergoing <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>. The study suggests the need for a new risk\u2010factor assessment in this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22274","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T18:46:40Z","timestamp":1395341200000},"page":"408-416","source":"Crossref","is-referenced-by-count":12,"title":["Time\u2010Trend Analysis on the Framingham Risk Score and Prevalence of Cardiovascular Risk Factors in Patients Undergoing Percutaneous Coronary Intervention Without Prior History of Coronary Vascular Disease Over the Last 17 Years: A Study From the Mayo Clinic <scp>PCI<\/scp> Registry"],"prefix":"10.1002","volume":"37","author":[{"given":"Moo\u2010Sik","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester Minnesota"},{"name":"Department of Preventive Medicine College of Medicine, Konyang University Daejeon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas J.","family":"Flammer","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan J.","family":"Lennon","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charanjit S.","family":"Rihal","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Lerman","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf133"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.25.3137"},{"key":"e_1_2_6_4_1","volume-title":"2003 Heart and Stroke Statistical Update","author":"American Heart Association","year":"2004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.09.098"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.10.044"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.699579"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2009.00157.x"},{"key":"e_1_2_6_9_1","volume-title":"Third Report of the National Cholesterol Education Program (NCEP)","author":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","year":"2002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_2_6_11_1","first-page":"e1002","article-title":"et al; 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