{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:37:54Z","timestamp":1791005874807,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T00:00:00Z","timestamp":1405641600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Patients with chronic kidney disease (CKD<\/jats:styled-content>) are at increased risk of life\u2010threatening cardiovascular arrhythmias. Although these arrhythmias are usually secondary to structural heart diseases that are commonly associated with CKD<\/jats:styled-content>, a significant proportion of cases with sudden cardiac death have no obvious structural heart disease. This study aims to explore the relationship of cardiac repolarization in patients with CKD<\/jats:styled-content> and worsening kidney function.<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>There is cardiac repolarization abnormalities among patients with chronic kidney disease.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a retrospective, chart\u2010review study of admissions or clinic visits to a university hospital between 2005 and 2010 by patients with a diagnosis of CKD<\/jats:styled-content>. Inclusion criteria selected patients who had 12\u2010lead surface electrocardiography (ECG<\/jats:styled-content>), renal function tests within 24 hours, and transthoracic echocardiography within 6 months. Cases with a documented etiology for the corrected Qt (Qtc) interval prolongation including structural heart disease, QT<\/jats:styled-content> prolonging drugs, or relevant disease conditions, were excluded.<\/jats:p><\/jats:sec>Results<\/jats:title>Our sample size was 154 ECGs<\/jats:styled-content>. Two\u2010thirds of patients with CKD<\/jats:styled-content> had QTc<\/jats:styled-content> interval prolongation, and about 20% had a QTc<\/jats:styled-content> interval >500 ms. QTc<\/jats:styled-content> interval was significantly different and increased with each successive stage of CKD<\/jats:styled-content> using the Bazett (P<\/jats:italic> < 0.006) or Fridericia (P<\/jats:italic> = 0.03) formula. QTc<\/jats:styled-content> interval correlated significantly with serum creatinine (P<\/jats:italic> = 0.01). These finding were independent of age, gender, potassium, and calcium concentrations.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The progression of CKD<\/jats:styled-content> resulted in a significant delay of cardiac repolarization, independent of other risk factors. This effect may potentially increase the risk of sudden cardiac death, and may also increase the susceptibility of drug\u2010induced arrhythmia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22277","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T22:12:40Z","timestamp":1405721560000},"page":"417-421","source":"Crossref","is-referenced-by-count":37,"title":["Cardiac Repolarization Abnormalities Among Patients With Various Stages of Chronic Kidney Disease"],"prefix":"10.1002","volume":"37","author":[{"given":"Khaled A.","family":"Sherif","sequence":"first","affiliation":[{"name":"Department of Geriatrics University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsayed","family":"Abo\u2010Salem","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Cincinnati Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragesh","family":"Panikkath","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Texas Tech University Health Sciences Center Lubbock, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musab","family":"Nusrat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Texas Tech University Health Sciences Center Lubbock, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryem","family":"Tuncel","sequence":"additional","affiliation":[{"name":"Department of Nephrology University of Connecticut Farmington, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,18]]},"reference":[{"issue":"1","key":"e_1_2_6_2_1","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"39","author":"National Kidney Foundation","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005101085"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2003.50004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.32005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.02.459"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00274-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.11.1585"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl587"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01455-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1155"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20768"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2005.00362.x"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22277","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T16:05:37Z","timestamp":1696608337000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1002\/clc.22277"],"URL":"https:\/\/doi.org\/10.1002\/clc.22277","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}