{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:23:24Z","timestamp":1787509404638,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Platypnea\u2010orthodeoxia syndrome (\n                    <jats:styled-content style=\"fixed-case\">POS<\/jats:styled-content>\n                    ) is a rare but clinically important form of dyspnea. The syndrome is characterized by dyspnea and arterial oxygen desaturation that occurs in the upright position and improves with recumbency. In cardiac\n                    <jats:styled-content style=\"fixed-case\">POS<\/jats:styled-content>\n                    , an atrial septal defect or patent foramen ovale allows communication between the right\u2010 and left\u2010sided circulations. A second defect, such as a dilated aorta, prominent eustachian valve, or pneumonectomy, then contributes to right\u2010to\u2010left shunting through the interatrial connection. Diagnosis is made through pulse oximetry to confirm orthodeoxia and through transesophageal echocardiography with bubble study to visualize the shunt. Although data are limited for this rare syndrome, percutaneous closure has thus far proven safe and effective.\n                  <\/jats:p>","DOI":"10.1002\/clc.22301","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T07:44:38Z","timestamp":1402299878000},"page":"645-649","source":"Crossref","is-referenced-by-count":57,"title":["Cardiac Platypnea\u2010Orthodeoxia Syndrome: An Often Unrecognized Malady"],"prefix":"10.1002","volume":"37","author":[{"given":"Joseph T.","family":"Knapper","sequence":"first","affiliation":[{"name":"Department of Medicine and Division of Cardiology) Emory University  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Schultz","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladwin","family":"Das","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence S.","family":"Sperling","sequence":"additional","affiliation":[{"name":"Department of Medicine and Division of Cardiology) Emory University  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,9]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Elixhauser A OwensP. Reasons for being admitted to the hospital through the emergency department 2003. HCUP statistical brief #2. February 2006.Agency for Healthcare Research and Quality;Rockville MD.http:\/\/www.hcup\u2010us.ahrq.gov\/reports\/statbriefs\/sb2.pdf. 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