{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:43:39Z","timestamp":1788896619385,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T00:00:00Z","timestamp":1410998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Improvement in the left ventricular ejection fraction (LVEF<\/jats:styled-content>) may occur in patients with dilated cardiomyopathy (DCM<\/jats:styled-content>).<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>There are different implications of persistent versus transient improvement in LVEF<\/jats:styled-content> among DCM<\/jats:styled-content> patients receiving contemporary therapy.<\/jats:p><\/jats:sec>Methods<\/jats:title>We studied 188 patients with nonischemic DCM<\/jats:styled-content>. Persistent improvement in LVEF<\/jats:styled-content> (PIEF<\/jats:styled-content>) was defined as LVEF<\/jats:styled-content> increase by at least 10% compared to baseline, and found in 2 separate echo\u2010Doppler exams performed at least 12 months apart. Increased LVEF<\/jats:styled-content> in echo 2, which was not sustained in echo 3, was defined as transient improvement in LVEF<\/jats:styled-content> (TIEF<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Over an average follow\u2010up of 6.8\u2009years, PIEF<\/jats:styled-content> occurred in 61 (33%) patients, predicting a better long\u2010term outcome (P<\/jats:italic> < 0.001) in a combined end\u2010point comprising death, heart transplantation, or the need for a ventricular assist device. The TIEF<\/jats:styled-content> group had an intermediate course and were closer to nonimprovers (P<\/jats:italic> = 0.003 vs PIEF<\/jats:styled-content>). Multivariate logistic regression identified the following independent predictors of PIEF<\/jats:styled-content>: shorter disease duration, pregnancy\u2010associated disease, left ventricular hypertrophy, and baseline LVEF<\/jats:styled-content> \u226425%. A score to predict PIEF<\/jats:styled-content> assigned 1 point to each of the following: disease duration <3\u2009years and no familial cardiomyopathy; pregnancy\u2010associated presentation; basal LVEF<\/jats:styled-content> \u226425%; and left ventricular wall thickness \u226512. A score of \u22653 was present in 44% of the patients, reliably predicting PIEF<\/jats:styled-content> in 91% (P<\/jats:italic> = 0.01).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Persistent improvement in LVEF<\/jats:styled-content> is associated with improved long\u2010term prognosis. Baseline clinical parameters can be used to identify patients likely to demonstrate PIEF<\/jats:styled-content>, thereby allowing tailored management in this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22331","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T10:12:25Z","timestamp":1411553545000},"page":"687-692","source":"Crossref","is-referenced-by-count":10,"title":["Predictors and Outcome of Sustained Improvement in Left Ventricular Function in Dilated Cardiomyopathy"],"prefix":"10.1002","volume":"37","author":[{"given":"Ido","family":"Blechman","sequence":"first","affiliation":[{"name":"Heart Failure Institute and Leviev Heart Center, Sheba Medical Center and Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Arad","sequence":"additional","affiliation":[{"name":"Heart Failure Institute and Leviev Heart Center, Sheba Medical Center and 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