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The impact of all these factors on clinical outcomes or disability evolution is not sufficiently known. <jats:styled-content style=\"fixed-case\">FRAIL\u2010HF<\/jats:styled-content> is a prospective observational cohort study designed to evaluate clinical outcomes (mortality and readmission), functional evolution, quality of life, and use of social resources at 1, 3, 6, and 12 months after admission in nondependent elderly patients hospitalized for <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>. Clinical features, medical treatment, self\u2010care ability, and health literacy were prospectively evaluated and a comprehensive geriatric assessment with special focus on frailty was systematically performed in hospital to assess interactions and relationships with postdischarge outcomes. Between May 2009 and May 2011, 450 consecutive patients with a mean age of 80\u2009\u00b1\u20096\u2009years were enrolled. Comorbidity was high (mean Charlson index, 3.4\u2009\u00b1\u20092.9). Despite being nondependent, 118 (26%) had minor disability for basic activities of daily living, only 76 (16.2%) had no difficulty in walking 400 meters, and 340 (75.5%) were living alone or with another elderly person. In addition, 316 patients (70.2%) fulfilled frailty criteria. Even nondependent older patients hospitalized for <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> show a high prevalence of clinical and nonclinical factors that may influence prognosis and are usually not considered in routine clinical practice. The results of <jats:styled-content style=\"fixed-case\">FRAIL\u2010HF<\/jats:styled-content> will provide important information about the relationship between these factors and different postdischarge clinical, functional, and quality\u2010of\u2010life outcomes.<\/jats:p>","DOI":"10.1002\/clc.22345","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T19:14:10Z","timestamp":1418757250000},"page":"725-732","source":"Crossref","is-referenced-by-count":77,"title":["<scp>FRAIL\u2010HF<\/scp>, a Study to Evaluate the Clinical Complexity of Heart Failure in Nondependent Older Patients: Rationale, Methods and Baseline Characteristics"],"prefix":"10.1002","volume":"37","author":[{"given":"Mar\u00eda T.","family":"Vid\u00e1n","sequence":"first","affiliation":[{"name":"Department of Geriatrics Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00edsabet","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Fern\u00e1ndez\u2010Avil\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Cardiology Gregorio Mara\u00f1\u00f3n University General Hospital Health Research Institute of the Gregorio Mara\u00f1\u00f3n Hospital Madrid Spain"},{"name":"Universidad Complutense de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Serra\u2010Rexach","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Bueno","sequence":"additional","affiliation":[{"name":"Department of Cardiology Gregorio Mara\u00f1\u00f3n University General Hospital Health Research Institute of the Gregorio Mara\u00f1\u00f3n Hospital Madrid Spain"},{"name":"Universidad Complutense de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a015172"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.03.061"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.748"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.216476"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.17.2115"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.8.847"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.19.2581"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00151-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01498-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22180"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2011.227504"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.01.375"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.066"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.865022"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.08.009"},{"key":"e_1_2_7_17_1","first-page":"767","article-title":"Revalidation and standardization of the cognition mini\u2010exam (first Spanish version of the Mini\u2010Mental Status Examination) in the general geriatric population [article in Spanish; 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