{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T08:25:56Z","timestamp":1721636756951},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>Radiation\u2010treated head and neck cancer (HNC<\/jats:styled-content>) patients are at high risk for developing radiation vasculopathy, as evidenced by an increased stroke risk. The benefits of screening and assessing the cardiovascular (CV<\/jats:styled-content>) risk of HNC<\/jats:styled-content> patients using carotid intima\u2010media thickness (CIMT<\/jats:styled-content>) ultrasound are not known. Our objective was to determine the prevalence of high CV<\/jats:styled-content> risk in patients without known CV<\/jats:styled-content> diseases who received radiation for HNC<\/jats:styled-content>, determine the percentage of screened patients who had a change in clinical management as a result of an increased CIMT<\/jats:styled-content>, and to compare this risk\u2010assessment tool to patients' risk classification using the Framingham Risk Score (FRS<\/jats:styled-content>) and Pooled Cohort Atherosclerotic Cardiovascular Disease (ASCVD<\/jats:styled-content>) Risk Equation (recommended by American College of Cardiology\/American Heart Association Guidelines on the Assessment of Cardiovascular Risk).<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>Risk calculators may not accurately predict risk in this population with a unique risk factor. Carotid IMT may be used to detect radiation vasculopathy in HNC patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Retrospective medical chart review was conducted on 134 radiation\u2010treated HNC<\/jats:styled-content> patients. The main outcome measures were CV<\/jats:styled-content> risk (as determined by CIMT<\/jats:styled-content>) and clinical management. Also, the FRS<\/jats:styled-content> and the Pooled Cohort ASCVD<\/jats:styled-content> Risk Equation were used to compare classification with CIMT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Approximately 74% of the cases were at high CV<\/jats:styled-content> risk using CIMT<\/jats:styled-content> technique. Approximately half of the HNC<\/jats:styled-content> patients screened had a change in clinical management characterized by recorded initiation of aspirin and recorded initiation or increase of statin therapies. The FRS<\/jats:styled-content> and the Pooled Cohort ASCVD<\/jats:styled-content> Risk Equation failed to detect 40% to 50% of cases found to be at high risk using the CIMT<\/jats:styled-content> technique.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Carotid IMT<\/jats:styled-content> identified a much greater percentage of radiation\u2010treated HNC<\/jats:styled-content> patients at high CV<\/jats:styled-content> risk compared with standard CV<\/jats:styled-content>\u2010risk calculators. By more accurately identifying the patients at high risk, this may lead to more effective prevention, and therefore a reduction in CV<\/jats:styled-content> events.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22389","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T11:11:20Z","timestamp":1431342680000},"page":"280-284","source":"Crossref","is-referenced-by-count":9,"title":["Carotid Intima\u2010Media Thickness Measurement Promises to Improve Cardiovascular Risk Evaluation in Head and Neck Cancer Patients"],"prefix":"10.1002","volume":"38","author":[{"given":"Douglas","family":"Jacoby","sequence":"first","affiliation":[{"name":"Department of Cardiology Penn Presbyterian Medical Center Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihane","family":"Hajj","sequence":"additional","affiliation":[{"name":"Department of Cardiology Penn Presbyterian Medical Center Philadelphia, 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