{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:55:16Z","timestamp":1787921716430,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T00:00:00Z","timestamp":1423785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence and contemporary trends of pre\u2013heart transplantation (<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>) coagulopathy and associated clinical outcomes have not been studied from a national database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Pre\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> coagulopathy is associated with increased in\u2010hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 2454 adult <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> recipients from the 2003 to 2010 Nationwide Inpatient Sample databases, 707 (29%) had pre\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> coagulopathy (defined as a comorbidity variable, based on International Classification of Diseases, Ninthe Revision, Clinical Modification and Diagnosis Related Group codes). We used propensity scores for coagulopathy to assemble a matched cohort of 664 pairs of patients with and without coagulopathy balanced in 54 baseline characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of pre\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> coagulopathy increased from 17% in 2003 to 44% in 2010 (<jats:italic>P<\/jats:italic> for trend &lt;0.001). In\u2010hospital mortality occurred in 8.6% and 4.7% of matched <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> recipients with and without coagulopathy, respectively (hazard ratio: 1.81; 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 1.17\u20102.80; <jats:italic>P<\/jats:italic> = 0.008). Coagulopathy was not significantly associated with post\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> graft complications (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>]: 1.20; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.95\u20101.52; <jats:italic>P<\/jats:italic> = 0.131) but was associated with increased blood transfusions (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.92; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.54\u20132.41; <jats:italic>P<\/jats:italic> &lt; 0.001). Coagulopathy and no\u2010coagulopathy groups had no difference in median length of stay (22 days in each group, <jats:italic>P<\/jats:italic> = 0.746), but median total hospital charges were higher among patients with coagulopathy compared to those without (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$425 643 vs <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$389 656; <jats:italic>P<\/jats:italic> = 0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this national study of <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> recipients, pretransplant coagulopathy was common, increased over time, and was not significantly associated with post\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> graft complications or increased hospital stay. However, it was associated with increased bleeding risk, in\u2010hospital mortality, and total hospital charges. These findings may have implications for the selection of patients for <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22391","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T20:27:06Z","timestamp":1423859226000},"page":"300-308","source":"Crossref","is-referenced-by-count":10,"title":["Pretransplant Coagulopathy and In\u2010hospital Outcomes Among Heart Transplant Recipients: A Propensity\u2010Matched Nationwide Inpatient Sample Study"],"prefix":"10.1002","volume":"38","author":[{"given":"Marjan","family":"Mujib","sequence":"first","affiliation":[{"name":"Department of Medicine, New York Medical College  Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel","family":"Khanna","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York Medical College  Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila K.","family":"Mazumder","sequence":"additional","affiliation":[{"name":"Department of Medicine, Flushing Hospital Medical Center  Flushing, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilbert S.","family":"Aronow","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York Medical College  Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhaval","family":"Kolte","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York Medical College  Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Khera","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York Medical College  Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrasekar","family":"Palaniswamy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Mount Sinai Medical Center  New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diwakar","family":"Jain","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York Medical College  Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg M.","family":"Lanier","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York Medical College  Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Sule","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York Medical College  Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington DC VA Medical Center  Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne C.","family":"Levy","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Washington  Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumanth D.","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, University of Alabama at Birmingham  Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York Medical College  Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio A.","family":"Panza","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York Medical College  Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan L.","family":"Gass","sequence":"additional","affiliation":[{"name":"Division of Cardiology, New York Medical College  Valhalla, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg C.","family":"Fonarow","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles  Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03042.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.08.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.08.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.06.018"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina46090091"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1284434"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00086-Z"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1104277"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.070"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.07.002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.877597"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.08.019"},{"key":"e_1_2_6_14_1","first-page":"116","article-title":"Intra\u2010aortic balloon pump use and outcomes with current therapies","volume":"23","author":"Vales L","year":"2011","journal-title":"J Invasive Cardiol."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.040246"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2004.09.012"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.018226"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.10.005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12746"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000282775.38626.13"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2012.03.030"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.11.020"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181e8fd75"},{"key":"e_1_2_6_24_1","unstructured":"BarrettM WilsonE WhalenD.2007 HCUP Nationwide Inpatient Sample (NIS) Comparison Report. HCUP Methods Series Report # 2010\u201303. Online September 9 2010. U.S. Agency for Healthcare Research and Quality. Available:http:\/\/www.hcup-us.ahrq.gov\/reports\/methods.jsp. Accessed November 1 2014."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199801000-00004"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000118861.56848.ee"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200107000-00009"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/70.1.41"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020363010465"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.108.790634"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr031"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.23.3130"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2010.530685"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.12.017"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.045"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00128-4"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20694"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22391","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:23:30Z","timestamp":1696335810000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,13]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1002\/clc.22391"],"URL":"https:\/\/doi.org\/10.1002\/clc.22391","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,13]]}}}