{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:47:33Z","timestamp":1792442853971,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD12\/0042\/0068;RS12\/0042\/0010;RD12\/0042\/0069;RD12\/0042\/0049;RD12\/0042\/0063"],"award-info":[{"award-number":["RD12\/0042\/0068;RS12\/0042\/0010;RD12\/0042\/0069;RD12\/0042\/0049;RD12\/0042\/0063"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>Vitamin K antagonists (VKA<\/jats:styled-content>) have a narrow therapeutic range, and literature analysis reveals poor quality of anticoagulation control. We sought to assess the prevalence of poor anticoagulant control in patients under VKA<\/jats:styled-content> treatment in the prevention of stroke for atrial fibrillation (AF<\/jats:styled-content>).<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>Control of anticoagulation with VKA is inadequate in a high percentage of patients with AF.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients with AF<\/jats:styled-content> under VKA<\/jats:styled-content> treatment were prospectively recruited in this observational registry. The sample comprised 948 patients. The estimated time spent in the therapeutic range (TTR<\/jats:styled-content>) was calculated, and variables related with a TTR<\/jats:styled-content> >65% were analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean age was 73.8 \u00b1 9.4 years, and 42.5% of the patients were women. Mean TTR<\/jats:styled-content> was 63.77% \u00b1 23.80% for the direct method and 60.27% \u00b1 24.48% for the Rosendaal method. Prevalence of poor anticoagulation control was 54%. Variables associated with good anticoagulation control were university studies (odds ratio [OR<\/jats:styled-content>]: 1.99, 95% confidence interval [CI<\/jats:styled-content>]: 1.08\u20103.64), chronic hepatic disease (OR<\/jats:styled-content>: 8.15, 95% CI<\/jats:styled-content>: 1.57\u201042.24), low comorbidity expressed as Charlson index (OR<\/jats:styled-content>: 0.87, 95% CI<\/jats:styled-content>: 0.76\u20100.99), no previous cardiac disease (OR<\/jats:styled-content>: 0.64, 95% CI<\/jats:styled-content>: 0.41\u20100.98), lower risk of bleeding assessed as hypertension, abnormal renal\/liver function, stroke, bleeding history or predisposition, labile international normalized ratio, elderly age, and use of drugs or alcohol (HAS\u2010BLED<\/jats:styled-content>; OR<\/jats:styled-content>: 0.81, 95% CI<\/jats:styled-content>: 0.69\u20100.95), and lower heart rate (OR<\/jats:styled-content>: 0.99, 95% CI<\/jats:styled-content>: 0.98\u20100.99).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Patients who receive VKA<\/jats:styled-content> to prevent stroke for AF<\/jats:styled-content> spend less than half the time within therapeutic range.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22397","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T13:07:11Z","timestamp":1431349631000},"page":"357-364","source":"Crossref","is-referenced-by-count":67,"title":["Quality of Anticoagulation With Vitamin K Antagonists"],"prefix":"10.1002","volume":"38","author":[{"given":"Vicente","family":"Bertomeu\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Cardiology San Juan University Hospital, Miguel Hern\u00e1ndez University Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Anguita","sequence":"additional","affiliation":[{"name":"Department of Cardiology Research Agency of the Spanish Society of Cardiology Madrid Spain"},{"name":"Department of Cardiology University Hospital Reina Sof\u00eda C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Moreno\u2010Arribas","sequence":"additional","affiliation":[{"name":"Department of Cardiology San Juan University Hospital, Miguel Hern\u00e1ndez University Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Cequier","sequence":"additional","affiliation":[{"name":"Department of Cardiology Research Agency of the Spanish Society of Cardiology Madrid Spain"},{"name":"Department of Cardiology Bellvitge University Hospital, L'Hospitalet de Llobregat Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Mu\u00f1iz","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Institute in Health Sciences, University of A Coru\u00f1a, A Coru\u00f1a Biomedical Research Institute A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Castillo\u2010Castillo","sequence":"additional","affiliation":[{"name":"Department of Cardiology San Juan University Hospital, Miguel Hern\u00e1ndez University Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Sanchis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Clinic of Val\u00e8ncia, University of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Rold\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital La Paz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Marin","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Virgen de la Arrixaca Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Bertomeu\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Cardiology San Juan University Hospital, Miguel Hern\u00e1ndez University Alicante Spain"},{"name":"Department of Cardiology Research Agency of the Spanish Society of Cardiology Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the FANTASIIA Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,11]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"486","article-title":"Incidence and prevalence of atrial fibrillation: an analysis based on 8.3 million patients","volume":"15","author":"Wilke T","year":"2013","journal-title":"Eur Soc Cardiol"},{"key":"e_1_2_6_3_1","first-page":"12","article-title":"Quality of vitamin K antagonist control and outcomes in 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