{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:31:27Z","timestamp":1762079487331,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T00:00:00Z","timestamp":1431993600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","award":["M245"],"award-info":[{"award-number":["M245"]}],"id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"ABSTRACT<\/jats:title>Novel therapies capable of reducing myocardial infarct (MI<\/jats:styled-content>) size when administered prior to reperfusion are required to prevent the onset of heart failure in ST<\/jats:styled-content>\u2010segment elevation myocardial infarction (STEMI<\/jats:styled-content>) patients treated by primary percutaneous coronary intervention (PPCI<\/jats:styled-content>). Experimental animal studies have demonstrated that mineralocorticoid receptor antagonist (MRA<\/jats:styled-content>) therapy administered prior to reperfusion can reduce MI<\/jats:styled-content> size, and MRA<\/jats:styled-content> therapy prevents adverse left ventricular (LV<\/jats:styled-content>) remodeling in post\u2010MI<\/jats:styled-content> patients with LV<\/jats:styled-content> impairment. With these 2 benefits in mind, we hypothesize that initiating MRA<\/jats:styled-content> therapy prior to PPCI<\/jats:styled-content>, followed by 3 months of oral MRA<\/jats:styled-content> therapy, will reduce MI<\/jats:styled-content> size and prevent adverse LV<\/jats:styled-content> remodeling in STEMI<\/jats:styled-content> patients. The MINIMISE\u2010STEMI<\/jats:styled-content> trial is a prospective, randomized, double\u2010blind, placebo\u2010controlled trial that will recruit 150 STEMI<\/jats:styled-content> patients from four centers in the United Kingdom. Patients will be randomized to receive either an intravenous bolus of MRA<\/jats:styled-content> therapy (potassium canrenoate 200 mg) or matching placebo prior to PPCI<\/jats:styled-content>, followed by oral spironolactone 50 mg once daily or matching placebo for 3 months. A cardiac magnetic resonance imaging scan will be performed within 1 week of PPCI<\/jats:styled-content> and repeated at 3 months to assess MI<\/jats:styled-content> size and LV<\/jats:styled-content> remodeling. Enzymatic MI<\/jats:styled-content> size will be estimated by the 48\u2010hour area\u2010under\u2010the\u2010curve serum cardiac enzymes. The primary endpoint of the study will be MI<\/jats:styled-content> size on the 3\u2010month cardiac magnetic resonance imaging scan. The MINIMISE STEMI<\/jats:styled-content> trial will investigate whether early MRA<\/jats:styled-content> therapy, initiated prior to reperfusion, can reduce MI<\/jats:styled-content> size and prevent adverse post\u2010MI LV<\/jats:styled-content> remodeling.<\/jats:p>","DOI":"10.1002\/clc.22401","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T18:43:12Z","timestamp":1432060992000},"page":"259-266","source":"Crossref","is-referenced-by-count":11,"title":["Mineralocorticoid Receptor Antagonist Pretreatment to MINIMISE<\/scp> Reperfusion Injury After ST<\/scp>\u2010Elevation Myocardial Infarction (The MINIMISE STEMI<\/scp> Trial): Rationale and Study Design"],"prefix":"10.1002","volume":"38","author":[{"given":"Heerajnarain","family":"Bulluck","sequence":"first","affiliation":[{"name":"Department of Cardiology Heart Hospital London United Kingdom"},{"name":"National Institute of Health Research University College London Hospitals Biomedical Research 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