{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:31:33Z","timestamp":1768879893931,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The optimal antithrombotic regimen remains controversial in patients taking oral anticoagulation (<jats:styled-content style=\"fixed-case\">OAC<\/jats:styled-content>) undergoing coronary stenting. This study sought to compare efficacy and safety outcomes of triple therapy (<jats:styled-content style=\"fixed-case\">OAC<\/jats:styled-content>, aspirin, and clopidogrel) vs dual therapy (clopidogrel with aspirin or <jats:styled-content style=\"fixed-case\">OAC<\/jats:styled-content>) in these patients. We hypothesize <jats:styled-content style=\"fixed-case\">OAC<\/jats:styled-content> plus clopidogrel could be the optimal regimen for patients with indications for <jats:styled-content style=\"fixed-case\">OAC<\/jats:styled-content> receiving stent implantation. Medline, the Cochrane Library, and other Internet sources were searched for clinical trials comparing the efficacy and safety of triple vs dual therapy for patients taking <jats:styled-content style=\"fixed-case\">OAC<\/jats:styled-content> after coronary stenting. Sixteen eligible trials including 9185 patients were identified. The risks of major adverse cardiac events (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>]: 1.06, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 0.82\u20101.39, <jats:italic>P<\/jats:italic> = 0.65), all\u2010cause mortality (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.98, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.76\u20101.27, <jats:italic>P<\/jats:italic> = 0.89), myocardial infarction (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.01, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.77\u20101.31, <jats:italic>P<\/jats:italic> = 0.97), and stent thrombosis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.91, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.49\u20101.69, <jats:italic>P<\/jats:italic> = 0.75) were similar between triple and dual therapy. Compared with dual therapy, triple therapy was associated with a reduced risk of ischemic stroke (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.57, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.35\u20100.94, <jats:italic>P<\/jats:italic> = 0.03) but with higher major bleeding (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.52, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.11\u20102.10, <jats:italic>P<\/jats:italic> = 0.01) and minor bleeding (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.59, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.05\u20102.42, <jats:italic>P<\/jats:italic> = 0.03). Subgroup analysis indicated there were similar ischemic stroke and major bleeding outcomes between triple therapy and therapy with <jats:styled-content style=\"fixed-case\">OAC<\/jats:styled-content> plus clopidogrel. Treatment with <jats:styled-content style=\"fixed-case\">OAC<\/jats:styled-content> and clopidogrel was associated with similar efficacy and safety outcomes compared with triple therapy. Triple therapy could be replaced by <jats:styled-content style=\"fixed-case\">OAC<\/jats:styled-content> plus clopidogrel without any concern about additional risk of thrombotic events.<\/jats:p>","DOI":"10.1002\/clc.22411","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T11:09:08Z","timestamp":1431428948000},"page":"499-509","source":"Crossref","is-referenced-by-count":23,"title":["Antithrombotic Regimens for Patients Taking Oral Anticoagulation After Coronary Intervention: A Meta\u2010analysis of 16 Clinical Trials and 9185 Patients"],"prefix":"10.1002","volume":"38","author":[{"given":"Xiao\u2010Fei","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Cardiology Nanjing First Hospital, Nanjing Medical University  Nanjing China"},{"name":"Department of Cardiology Nanjing Heart Center  Nanjing 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