{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T11:26:01Z","timestamp":1696591561195},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T00:00:00Z","timestamp":1441584000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association between preinfarction angina and angiographic findings has not been elucidated in patients with non\u2013<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u2010segment elevation myocardial infarction (<jats:styled-content style=\"fixed-case\">NSTEMI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Patients with preinfarction angina have favorable angiographic findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study analyzed 481 patients who underwent coronary angiography within 5 days of presenting <jats:styled-content style=\"fixed-case\">NSTEMI<\/jats:styled-content>. Preinfarction angina was defined as experiencing \u22651 chest\u2010pain episode within 7 days prior to admission. Infarct size was measured as the peak cardiac troponin I (<jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content>) level, and large myocardial infarction (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>) was defined as a peak <jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content> level &gt;85th percentile value in the study population. Infarct\u2010related artery (<jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content>) patency was defined as Thrombolysis In Myocardial Infarction grade 2 or 3 flow. Clinical and angiographic characteristics and in\u2010hospital mortality were compared between patients with and without preinfarction angina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 481 patients, 200 (42%) had preinfarction angina. Preinfarction angina was associated with smaller infarct size, indicated by lower peak <jats:styled-content style=\"fixed-case\">cTnI<\/jats:styled-content> levels (<jats:italic>P<\/jats:italic> = 0.006) and lower incidence of large <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.02), and <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content> patency (<jats:italic>P<\/jats:italic> = 0.03). There was no significant difference in in\u2010hospital mortality. On multivariate analysis, both preinfarction angina (odds ratio: 0.53, 95% confidence interval: 0.29\u20100.94, <jats:italic>P<\/jats:italic> = 0.03) and <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content> patency (odds ratio: 0.30, 95% confidence interval: 0.17\u20100.52, <jats:italic>P<\/jats:italic> &lt; 0.001) were independent negative predictors of large <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrates that preinfarction angina is a predictor of smaller infarct size and infarct\u2010related artery patency in <jats:styled-content style=\"fixed-case\">NSTEMI<\/jats:styled-content> patients, suggesting that <jats:styled-content style=\"fixed-case\">NSTEMI<\/jats:styled-content> patients presenting without preinfarction angina are at increased risk of developing a large <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22439","type":"journal-article","created":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T08:34:51Z","timestamp":1441614891000},"page":"535-541","source":"Crossref","is-referenced-by-count":8,"title":["Association Between Preinfarction Angina and Angiographic Findings in Non\u2013ST\u2010Segment Elevation Myocardial Infarction"],"prefix":"10.1002","volume":"38","author":[{"given":"Naoki","family":"Misumida","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Mount Sinai Beth Israel  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mount Sinai Beth Israel  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeeha","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of 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