{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:13:11Z","timestamp":1788232391386,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The role of warfarin in anterior <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u2010segment elevation myocardial infarction (<jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>) complicated by left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) dysfunction in patients treated with primary percutaneous coronary intervention (<jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>) and dual antiplatelet therapy is unclear. Warfarin may prevent cardioembolic events but significantly increases bleeding in the setting of dual antiplatelet therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>The incidence of <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> thrombus in anterior <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content> patients treated with <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content> is low, and clinical predictors might be valuable in determining patients at risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective, single\u2010center study of 687 consecutive patients with anterior <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content> treated with <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content> from 2006 to 2013. Baseline variables were evaluated in 310 patients at high risk for <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> thrombus based on echocardiographic criteria. Patients with definite, probable, and no <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> thrombus were compared by <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content>, \u03c7<jats:sup>2<\/jats:sup>, or <jats:italic>t<\/jats:italic> test where appropriate. Logistic regression analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> thrombus was 15% (n\u2009=\u200947 probable\/definite thrombus). Cardiac arrest was the only independent characteristic associated with increased risk of <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> thrombus (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>]: 4.06, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 1.3\u201012.7). Trends were observed for a lower risk in cardiogenic shock (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.33, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.10\u20101.05) and aspirin use at baseline (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.43, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.17\u20101.1). Treatment variables associated with <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> thrombus included unfractionated heparin use post\u2010<jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 2.43, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.16\u20105.1) and use of balloon angioplasty without stent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In contemporary practice with primary <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>, definite <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> thrombus following anterior <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> dysfunction is challenging to predict. Further investigation is needed to determine if there is a subset of patients that should be treated with prophylactic warfarin.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22450","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:45:25Z","timestamp":1441932325000},"page":"590-597","source":"Crossref","is-referenced-by-count":30,"title":["Incidence and Predictors of Left Ventricular Thrombus After Primary Percutaneous Coronary Intervention for Anterior <scp>ST<\/scp>\u2010Segment Elevation Myocardial Infarction"],"prefix":"10.1002","volume":"38","author":[{"given":"Adam","family":"Driesman","sequence":"first","affiliation":[{"name":"Cardiovascular Institute, Rhode Island Hospital, Warren Alpert Medical School Brown University  Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Hyder","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Rhode Island Hospital, Warren Alpert Medical School Brown University  Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Lang","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Rhode Island Hospital, Warren Alpert Medical School Brown University  Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Stockwell","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Rhode Island Hospital, Warren Alpert Medical School Brown University  Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena","family":"Poppas","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Rhode Island Hospital, Warren Alpert Medical School Brown University  Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dawn Abbott","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Rhode Island Hospital, Warren Alpert Medical School Brown University  Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-301962"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90409-T"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.11.019"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22411"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24776"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03625.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90463-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.2.512"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.07.018"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.03.020"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.11.016"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.06.043"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2014.01.030"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902093200604"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.02.007"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.10.046"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2007.11.004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62177-1"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22450","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:50:08Z","timestamp":1696337408000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,10]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/clc.22450"],"URL":"https:\/\/doi.org\/10.1002\/clc.22450","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,10]]}}}