{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T15:34:17Z","timestamp":1770996857641,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Bioresorbable stents are novel devices designed to overcome the long\u2010term limitations of permanent stent implantation. The Absorb bioresorbable vascular scaffold (<jats:styled-content style=\"fixed-case\">BVS<\/jats:styled-content>; Abbott Vascular, Santa Clara, <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>) was the first bioresorbable stent with Conformit\u00e9 Europ\u00e9enne mark approval in coronary vessels and has been the subject of multiple clinical studies. Despite its potential advantages, the safety and efficacy of <jats:styled-content style=\"fixed-case\">BVS<\/jats:styled-content> remain unclear. To address this, we conducted a systematic review to examine the safety and efficacy of <jats:styled-content style=\"fixed-case\">BVS<\/jats:styled-content>. The <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, Embase, Current Index to Nursing &amp; Allied Health Literature (<jats:styled-content style=\"fixed-case\">CINAHL<\/jats:styled-content>), Cochrane, and Science Citation Index Expanded (<jats:styled-content style=\"fixed-case\">SCIE<\/jats:styled-content>) databases were searched for studies examining <jats:styled-content style=\"fixed-case\">BVS<\/jats:styled-content> safety and efficacy. Our search was restricted to studies published in English or French. Outcomes of interest include cardiac death, myocardial infarction, target\u2010lesion revascularization, restenosis, and composite endpoints. Eleven studies met our inclusion criteria (n = 2990), which included 1 randomized controlled trial and 10 cohort studies (2 controlled). These studies varied in size (11\u20131189) and follow\u2010up duration (1\u201360 months). The incidence of major adverse cardiac events ranged from 2.6% to 15.5%, with no statistically significant difference between <jats:styled-content style=\"fixed-case\">BVS<\/jats:styled-content> and control in studies that included a comparison group. Although available data are limited, current evidence is promising and suggests that the use of <jats:styled-content style=\"fixed-case\">BVS<\/jats:styled-content> is not associated with a significant increase in major cardiac events in the short term. Numerous randomized controlled trials are currently in progress that will further improve our understanding of the safety and efficacy of this device.<\/jats:p>","DOI":"10.1002\/clc.22451","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T05:44:50Z","timestamp":1442987090000},"page":"48-55","source":"Crossref","is-referenced-by-count":11,"title":["The Safety and Efficacy of Absorb Bioresorbable Vascular Scaffold: A Systematic Review"],"prefix":"10.1002","volume":"39","author":[{"given":"Chang","family":"Lu","sequence":"first","affiliation":[{"name":"Faculty of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian B.","family":"Filion","sequence":"additional","affiliation":[{"name":"Faculty of Medicine McGill University  Montreal Quebec Canada"},{"name":"Division of Clinical Epidemiology Lady Davis Institute, Jewish General Hospital, McGill University  Montreal Quebec Canada"},{"name":"Department of Epidemiology, Biostatistics, and Occupational Health McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"Faculty of Medicine McGill University  Montreal Quebec Canada"},{"name":"Division of Clinical Epidemiology Lady Davis Institute, Jewish General Hospital, McGill University  Montreal Quebec Canada"},{"name":"Department of Epidemiology, Biostatistics, and Occupational Health McGill University  Montreal Quebec Canada"},{"name":"Division of Cardiology Jewish General Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-012-0295-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.1.14"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17275-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi571"},{"key":"e_1_2_7_6_1","first-page":"37","article-title":"Bioresorbable scaffolds in the treatment of coronary artery disease","volume":"6","author":"Zhang Y","year":"2013","journal-title":"Med Devices (Auckl)"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61455-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV9I9A176"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25569"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY14M07_11"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY14M08_08"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV9I11A217"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht546"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.05.017"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-013-0630-x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV9I4A80"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV10I12A243"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.05.050"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60325-1"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.971549"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.693739"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.921528"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6625"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV5IFA3"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV5I8A157"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60415-8"},{"key":"e_1_2_7_28_1","first-page":"301","article-title":"The ABSORB bioresorbable vascular scaffold: an evolution or revolution in interventional cardiology?","volume":"53","author":"Gogas BD","year":"2012","journal-title":"Hellenic J Cardiol."},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31053"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302598"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu140"},{"key":"e_1_2_7_32_1","unstructured":"Abbott completes enrollment of Absorb randomized clinical trials in the United States Japan and China [press release]. 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