{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:12:45Z","timestamp":1791850365965,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T00:00:00Z","timestamp":1444003200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300244"],"award-info":[{"award-number":["81300244"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400898"],"award-info":[{"award-number":["81400898"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>The prognostic significance of right bundle branch block (RBBB<\/jats:styled-content>) is inconsistent across studies. We aimed to assess the association between RBBB<\/jats:styled-content> (in general population and patients with heart disease) and risk of all\u2010cause mortality, cardiac death, acute myocardial infarction (MI<\/jats:styled-content>), and heart failure (HF<\/jats:styled-content>).<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>RBBB may be associated with increased risk of death.<\/jats:p><\/jats:sec>Methods<\/jats:title>PubMed<\/jats:styled-content>, EMBASE<\/jats:styled-content>, and the Cochrane Library up to February 2015 were searched for prospective cohort studies that reported RBBB<\/jats:styled-content> at baseline and all\u2010cause mortality, cardiac death, MI<\/jats:styled-content>, and HF<\/jats:styled-content> at follow\u2010up. A meta\u2010analysis of published data was undertaken primarily by means of fixed\u2010effects models.<\/jats:p><\/jats:sec>Results<\/jats:title>Nineteen cohort studies including 201\u2009437 participants were included with a mean follow\u2010up period ranging from 1 to 246 months. For general population with RBBB<\/jats:styled-content>, the pooled adjusted hazard ratio (HR<\/jats:styled-content>) for all\u2010cause mortality was 1.17 (95% confidence interval [CI<\/jats:styled-content>]: 1.03\u20131.33) compared with no BBB<\/jats:styled-content>. General population with RBBB<\/jats:styled-content> had an increased risk of cardiac death (HR<\/jats:styled-content>: 1.43, 95% CI<\/jats:styled-content>: 1.17\u20131.74). For patients with RBBB<\/jats:styled-content> and acute MI<\/jats:styled-content>, the pooled risk ratio was 2.31 (95% CI<\/jats:styled-content>: 2.13\u20132.49) for in\u2010hospital mortality, 2.85 (95% CI<\/jats:styled-content>: 2.46\u20133.30) for 30\u2010day mortality, and 1.96 (95% CI<\/jats:styled-content>: 1.59\u20132.42) for longer\u2010term mortality. For acute HF<\/jats:styled-content> patients, the pooled risk ratio of all\u2010cause mortality was 1.11 (95% CI<\/jats:styled-content>: 1.06\u20131.16), and for chronic HF<\/jats:styled-content> patients it was 1.75 (95% CI<\/jats:styled-content>: 1.38\u20132.22).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Right bundle branch block is associated with an increased risk of mortality in general population and patients with heart disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22454","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T12:31:12Z","timestamp":1444048272000},"page":"604-613","source":"Crossref","is-referenced-by-count":67,"title":["The Prognostic Significance of Right Bundle Branch Block: A Meta\u2010analysis of Prospective Cohort Studies"],"prefix":"10.1002","volume":"38","author":[{"given":"Yunyun","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Neurology, Jinling Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanjing Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme J.","family":"Hankey","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanjing Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanjing Drum Tower Hospital Medical School of Nanjing University Nanjing 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