{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:11:37Z","timestamp":1766268697573},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:00:00Z","timestamp":1447891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In coronary artery disease (CAD), medical treatment is the main clinical strategy for controlling ischemia and angina symptoms while restoring a satisfactory level of usual activities and improving quality of life (QOL). This study's purpose was to evaluate in CAD patients the antianginal efficacy of 4\u2010month treatment with ivabradine plus a \u03b2\u2010blocker and to record patient compliance and the effect of treatment on QOL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this noninterventional study, 2403 patients with chronic stable angina were prospectively studied from 245 private cardiology offices. Data were recorded at baseline and at 1 and 4 months after inclusion. Patient quality of life was assessed using the EuroQol 5 dimensions (EQ\u20105D) questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From baseline to study completion, mean heart rate decreased from 81.5 \u00b1 9.7 bpm to 63.9 \u00b1 6.0 bpm (P &lt;\u20100.001), mean number of anginal attacks decreased from 2.0 \u00b1 2.0 times\/wk to 0.2 \u00b1 0.6 times\/wk (P &lt; 0.001) and nitroglycerin consumption decreased from 1.4 \u00b1 2.0 times\/wk to 0.1 \u00b1 0.4 times\/wk (P &lt; 0.001). The percentage of patients with Canadian Cardiovascular Society angina class I increased from approximately 38% (baseline) to 84% (study completion; P &lt; 0.001). The reduction in anginal attacks, nitroglycerin consumption, and angina score was correlated with reduction in heart rate (P &lt; 0.001). The mean EQ\u20105D visual analogue scale index increased by 16.1 points (P &lt; 0.001), and compliance with treatment was high throughout the trial (96%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ivabradine administration on top of optimal individualized dose of \u03b2\u2010blockers is associated with decreased anginal events and with improvement of QOL in CAD patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22479","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T09:44:39Z","timestamp":1447926279000},"page":"725-732","source":"Crossref","is-referenced-by-count":12,"title":["Treatment of Stable Angina Pectoris With Ivabradine in Everyday Practice: A Pan\u2010Hellenic, Prospective, Noninterventional Study"],"prefix":"10.1002","volume":"38","author":[{"given":"John","family":"Zarifis","sequence":"first","affiliation":[{"name":"Cardiology Department \u201cGeorge Papanikolaou\u201d General Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violetta","family":"Grammatikou","sequence":"additional","affiliation":[{"name":"Medical Department Servier Hellas Pharmaceuticals Ltd.  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manolis","family":"Kallistratos","sequence":"additional","affiliation":[{"name":"Medical Department Servier Hellas Pharmaceuticals Ltd.  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apostolos","family":"Katsivas","sequence":"additional","affiliation":[{"name":"First Cardiology Department \u201cKorgialeneio\u2010Benakeio E.E.S.\u201d General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on Behalf of the Investigators of the Prospective, Noninterventional, Observational Study of the Antianginal Efficacy of Ivabradine During a 4\u2010Month Treatment of a Greek Population With Coronary Artery Disease","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/suq014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.2.135"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.2.140"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000143379.26342.5C"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00564.2002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.059717"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00547.2001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht296"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-011-0402-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi586"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-011-6327-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn571"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-3-32"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-6296(95)00038-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199711000-00002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2008.00356.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.079"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61171-X"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2009.084384"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.02.044"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi705"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61198-1"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01970-8"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(02)00743-1"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.168"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.746537"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304880"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.11.035"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22282"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014695"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422511"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22479","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22479","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.22479","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T02:05:12Z","timestamp":1696644312000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,19]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1002\/clc.22479"],"URL":"https:\/\/doi.org\/10.1002\/clc.22479","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"type":"print","value":"0160-9289"},{"type":"electronic","value":"1932-8737"}],"subject":[],"published":{"date-parts":[[2015,11,19]]}}}