{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T17:05:29Z","timestamp":1763226329418},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T00:00:00Z","timestamp":1451520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with sinus node dysfunction (SND) have increased risk of atrial tachyarrhythmias, including atrial fibrillation (AF). To date, treatment patterns and outcomes of patients with SND and AF have not been well described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Patients with SND and AF have higher risk of adverse cardiovascular outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sinus node dysfunction was defined clinically, based on treating physician. Treatment patterns were described and logistic regression analysis performed to assess outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 1710 (17.7%) out of 9631 patients had SND at enrollment. Patients with SND and AF had increased comorbid medical illnesses, more severe symptoms (European Heart Rhythm Association class IV: 17.5% vs 13.9%; <jats:italic>P<\/jats:italic> = 0.0007), and poorer quality of life (median 12\u2010month Atrial Fibrillation Effect on Quality of Life score: 79.6 vs 85.2; <jats:italic>P =<\/jats:italic> 0.0008). There were no differences in AF management strategy between patients with SND and those without (rate control, 69.7% vs 67.7%; rhythm control, 30.0% vs 32.0%; <jats:italic>P<\/jats:italic> = 0.11). After adjustment, patients with SND were more likely than those without SND to progress from paroxysmal AF at baseline to persistent or permanent AF at any follow\u2010up, or persistent AF at baseline to permanent AF at any follow\u2010up (odds ratio: 1.23, 95% confidence interval: 1.01\u20101.49, <jats:italic>P<\/jats:italic> = 0.035). However, there was no association between SND and major risk\u2010adjusted outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sinus node dysfunction is present in 1 of 6 patients with AF and is associated with increased comorbidities and higher symptom burden. However, SND is not associated with an increase in major risk\u2010adjusted outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22504","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T15:38:39Z","timestamp":1451576319000},"page":"119-125","source":"Crossref","is-referenced-by-count":8,"title":["Sinus Node Dysfunction Is Associated With Higher Symptom Burden and Increased Comorbid Illness: Results From the ORBIT\u2010AF Registry"],"prefix":"10.1002","volume":"39","author":[{"suffix":"II","given":"Larry R.","family":"Jackson","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute Duke University Medical Center  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University Medical Center  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Sr","given":"Jonathan P.","family":"Piccini","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University Medical Center  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard J.","family":"Gersh","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine, Division of Cardiovascular Medicine  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald V.","family":"Naccarelli","sequence":"additional","affiliation":[{"name":"Penn State University School of Medicine, Division of Cardiovascular Medicine  Hershey Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Reiffel","sequence":"additional","affiliation":[{"name":"Columbia University College of Physicians and Surgeons  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Freeman","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine, Division of Cardiovascular Medicine  New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laine","family":"Thomas","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University Medical Center  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Chang","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceuticals, Inc., Division of Internal Medicine  Raritan New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregg C.","family":"Fonarow","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of California Los Angeles  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan S.","family":"Go","sequence":"additional","affiliation":[{"name":"Kaiser Permanente, Kaiser Permanente Division of Research  Oakland California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth W.","family":"Mahaffey","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Stanford University School of Medicine  Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric D.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University Medical Center  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Kowey","sequence":"additional","affiliation":[{"name":"Lankenau Institute for Medical Research, Jefferson Medical College  Wynnewood Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003093421006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000090685.13169.07"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00800.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.15.1807"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00941.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus219"},{"key":"e_1_2_6_8_1","first-page":"162:606.e1","article-title":"Outcomes registry for better informed treatment of atrial fibrillation: rationale and design of ORBIT\u2010AF","author":"Piccini JP","year":"2011","journal-title":"Am Heart 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