{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:55:32Z","timestamp":1746320132476},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T00:00:00Z","timestamp":1458172800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>About 10% of patients admitted to a chest pain unit (<jats:styled-content style=\"fixed-case\">CPU<\/jats:styled-content>) exhibit atrial fibrillation (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>To determine whether calcium scores (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>) are superior over common risk scores for coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>) in patients presenting with atypical chest pain, newly diagnosed <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>, and intermediate pretest probability for <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> within the <jats:styled-content style=\"fixed-case\">CPU<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 73 subjects, <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> was related to the following risk scores: Global Registry of Acute Coronary Events (<jats:styled-content style=\"fixed-case\">GRACE<\/jats:styled-content>) score, including a new model of a frequency\u2010normalized approach; Thrombolysis In Myocardial Infarction score; European Society of Cardiology Systematic Coronary Risk Evaluation (<jats:styled-content style=\"fixed-case\">SCORE<\/jats:styled-content>); Framingham risk score; and Prospective Cardiovascular M\u00fcnster Study score. Revascularization rates during index stay were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> was 77 (interquartile range, 1\u2013270), with higher values in men and the left anterior descending artery. Only the modified <jats:styled-content style=\"fixed-case\">GRACE<\/jats:styled-content> (\u03c1 = 0.27; <jats:italic>P<\/jats:italic> = 0.02) and the <jats:styled-content style=\"fixed-case\">SCORE<\/jats:styled-content> (\u03c1 = 0.39; <jats:italic>P<\/jats:italic> &lt; 0.005) were significantly correlated with <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>, whereas the <jats:styled-content style=\"fixed-case\">GRACE<\/jats:styled-content> (\u03c4 = 0.21; <jats:italic>P<\/jats:italic> = 0.04) and modified <jats:styled-content style=\"fixed-case\">GRACE<\/jats:styled-content> (\u03c4 = 0.23; <jats:italic>P<\/jats:italic> = 0.02) scores were significantly correlated with percentile groups. Only the <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> significantly discriminated between those with and without stenosis (<jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Apart from modified <jats:styled-content style=\"fixed-case\">GRACE<\/jats:styled-content> score, overall correlations between risk scores and calcium burden, as well as revascularization rates during index stay, were low. By contrast, the determination of <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> may be used as an additional surrogate marker in risk stratification in <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> patients with intermediate pretest likelihood for <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> admitted to a <jats:styled-content style=\"fixed-case\">CPU<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22506","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T09:51:58Z","timestamp":1458640318000},"page":"157-164","source":"Crossref","is-referenced-by-count":6,"title":["Coronary Artery Calcium as an Independent Surrogate Marker in the Risk Assessment of Patients With Atrial Fibrillation and an Intermediate Pretest Likelihood for Coronary Artery Disease Admitted to a German Chest Pain Unit"],"prefix":"10.1002","volume":"39","author":[{"given":"Frank","family":"Breuckmann","sequence":"first","affiliation":[{"name":"Department of Cardiology, Arnsberg Medical Center  Arnsberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Olligs","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liane","family":"Hinrichs","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Arnsberg Medical Center  Arnsberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Koopmann","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lichtenberg","sequence":"additional","affiliation":[{"name":"Department of Angiology, Arnsberg Medical Center  Arnsberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"B\u00f6se","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Arnsberg Medical Center  Arnsberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Eckardt","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Waltenberger","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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