{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T11:26:36Z","timestamp":1781263596872,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T00:00:00Z","timestamp":1454630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atrial fibrillation (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>), a disease of the elderly, occasionally occurs at younger age. Pathophysiology of <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> in younger patients is diverse, including channelopathies and cardiomyopathies. Data on the significance and complications of <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> in young patients are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Atrial fibrillation is the first manifestation of cardiovascular disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>) in young patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 11 888 patients in a university hospital database, patients age \u226435 years were identified. A composite of stroke\/transient ischemic attack, thromboembolic events, major bleeding, and death was the primary endpoint. Stroke\/transient ischemic attack, thromboembolic events, major bleeding, death, <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> during follow\u2010up, diagnosis of arrhythmia other than <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>, and new diagnosis of any <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> were secondary endpoints.<\/jats:p><jats:p>Endpoints were compared between patients with and without comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 124 patients (29.1\u00b1 5 years). Of those, 84 were followed over 48.4 \u00b1 39.8 months. Comorbidities were present in 40.5%. Incidence of the primary endpoint was not different between the groups. Arrhythmias other than <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> were more common in patients without comorbidities (36% vs 14.7%; P = 0.032). A supraventricular tachycardia (<jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content>) was found in 57.1% of patients who underwent electrophysiological testing and was treated with catheter ablation. None of those patients had <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Atrial fibrillation occurs in young patients with and without structural heart disease. Young <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> patients without comorbidities rarely develop <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> during the first years after diagnosis. Yet, an <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content> is found in a high proportion of young <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> patients; <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> may be first manifestation of <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content>. Therefore, young patients should undergo further evaluation for <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content><\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22516","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T18:15:57Z","timestamp":1454696157000},"page":"229-233","source":"Crossref","is-referenced-by-count":11,"title":["Where There's Smoke, There's Fire? Significance of Atrial Fibrillation in Young Patients"],"prefix":"10.1002","volume":"39","author":[{"given":"Alexander","family":"Wutzler","sequence":"first","affiliation":[{"name":"Department of Cardiology Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Campus Virchow\u2010Klinikum Berlin"},{"name":"Cardiovascular Center St. Josef Hospital, Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"von Ulmenstein","sequence":"additional","affiliation":[{"name":"Department of Cardiology Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Campus Virchow\u2010Klinikum Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Attanasio","sequence":"additional","affiliation":[{"name":"Department of Cardiology Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Campus Virchow\u2010Klinikum 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