{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:41:24Z","timestamp":1758818484647},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>Despite improved long\u2010term safety of biodegradable polymer (BP<\/jats:styled-content>) drug\u2010eluting stents (DES<\/jats:styled-content>) compared to first\u2010generation durable polymer (DP<\/jats:styled-content>) DES<\/jats:styled-content>, data on the safety and efficacy of BP\u2010DES<\/jats:styled-content> compared with second\u2010generation (2G<\/jats:styled-content>) DP\u2010DES<\/jats:styled-content> in patients with acute myocardial infarction (AMI<\/jats:styled-content>) are limited.<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>To evaluate the safety and efficacy of BP\u2010DES<\/jats:styled-content> compared with 2G\u2010DP\u2010DES<\/jats:styled-content> in the higher stent thrombosis (ST<\/jats:styled-content>) risk setting of AMI<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 3359 AMI<\/jats:styled-content> patients who received either BP\u2010DES<\/jats:styled-content> (n = 261) or 2G\u2010DP\u2010DES<\/jats:styled-content> (n = 3098) were included from the Korea Acute Myocardial Infarction Registry (KAMIR<\/jats:styled-content>). Differences in baseline clinical and angiographic characteristics were adjusted using a 1:5 propensity score matching analysis (n = 261 for BP\u2010DES<\/jats:styled-content> and n = 1305 for 2G\u2010DP\u2010DES<\/jats:styled-content>). The primary outcome was the incidence of major adverse cardiac events (MACE<\/jats:styled-content>) including all\u2010cause death, recurrent myocardial infarction (re\u2010MI<\/jats:styled-content>), and target vessel revascularization (TVR<\/jats:styled-content>). The rate of definite or probable ST<\/jats:styled-content> was also investigated.<\/jats:p><\/jats:sec>Results<\/jats:title>In adjusted analysis, there was no significant difference between the 2 groups in baseline clinical and angiographic characteristics; 2\u2010year MACE<\/jats:styled-content> (10.7% and 9.9% in the BP\u2010DES<\/jats:styled-content> group and 2G\u2010DP\u2010DES<\/jats:styled-content> group, respectively, P<\/jats:italic> = 0.679); ST<\/jats:styled-content> incidence (0.8% vs 0.9%, respectively, P<\/jats:italic> = 1.0), and rates of all\u2010cause death, re\u2010MI<\/jats:styled-content>, and TVR<\/jats:styled-content>. By multivariate analysis, old age, diabetes mellitus, renal dysfunction, and left ventricular dysfunction were the independent predictors of MACE<\/jats:styled-content> after BP\u2010DES<\/jats:styled-content> or 2G\u2010DP\u2010DES<\/jats:styled-content> implantation.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>BP\u2010DES<\/jats:styled-content> and 2G\u2010DP\u2010DES<\/jats:styled-content> appear to have comparable 2\u2010year safety and efficacy for the treatment of AMI<\/jats:styled-content>. However, longer\u2010term follow\u2010up is needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22525","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T21:08:21Z","timestamp":1459458501000},"page":"276-284","source":"Crossref","is-referenced-by-count":5,"title":["Two\u2010Year Safety and Efficacy of Biodegradable Polymer Drug\u2010Eluting Stent Versus Second\u2010Generation Durable Polymer Drug\u2010Eluting Stent in Patients With Acute Myocardial Infarction: Data from the Korea Acute Myocardial Infarction Registry (KAMIR<\/scp>)"],"prefix":"10.1002","volume":"39","author":[{"given":"Seung\u2010Ho","family":"Hur","sequence":"first","affiliation":[{"name":"Division of Cardiology Keimyung University Dongsan Medical Center Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u2010Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Keimyung University Dongsan Medical Center Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki\u2010Bum","family":"Won","sequence":"additional","affiliation":[{"name":"Division of Cardiology Keimyung University Dongsan Medical Center Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Kyeong","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Cardiology Keimyung University Dongsan Medical Center Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyuck\u2010Jun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Cardiology Keimyung University Dongsan Medical Center Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Wook","family":"Nam","sequence":"additional","affiliation":[{"name":"Division of Cardiology Keimyung University Dongsan Medical Center Daegu South 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