{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:06:19Z","timestamp":1768014379278,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T00:00:00Z","timestamp":1457913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>Mineralocorticoid receptor antagonists (MRAs<\/jats:styled-content>) reduce morbidity and mortality in heart failure with reduced ejection fraction (HFrEF<\/jats:styled-content>). Their role in patients without heart failure, particularly in patients with coronary artery disease (CAD<\/jats:styled-content>) and preserved EF<\/jats:styled-content>, is still a matter of debate.<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>The MRA<\/jats:styled-content> eplerenone on top of standard medical therapy improves endothelial dysfunction and other markers of vascular health in CAD<\/jats:styled-content> patients with preserved EF<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this double\u2010blind, randomized, placebo\u2010controlled study, 42 patients (mean age: 63.5 \u00b1 9.1 years; 37 males) were randomized to 4\u2010week treatment with eplerenone 25 mg daily or placebo. The primary endpoint was difference in endothelial function as assessed by flow\u2010mediated dilatation (FMD<\/jats:styled-content>) of the brachial artery. Secondary endpoints included 24\u2010hour blood pressure (BP<\/jats:styled-content>), endothelial progenitor cells, and platelet adhesion.<\/jats:p><\/jats:sec>Results<\/jats:title>No difference in the primary endpoint FMD<\/jats:styled-content> was noted after 4 weeks of treatment with eplerenone compared with placebo (FMD<\/jats:styled-content>: 4.7% \u00b1 2.0% and 4.9% \u00b1 2.1%, respectively; P<\/jats:italic> = 0.77). There were no significant differences between eplerenone and placebo in 24\u2010hour BP<\/jats:styled-content> (mean systolic BP<\/jats:styled-content>: 126.9 \u00b1 17.3 and 123.3 \u00b1 9.7 mm Hg, P<\/jats:italic> = 0.41; diastolic BP<\/jats:styled-content>: 73.3 \u00b1 12.9 and 72.0 \u00b1 7.5 mm Hg, respectively, P<\/jats:italic> = 0.69), number of endothelial progenitor cells, and platelet adhesion.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Adding low\u2010dose eplerenone to standard medical therapy did not improve important markers of vascular health in patients with CAD<\/jats:styled-content> and preserved EF<\/jats:styled-content>. Our results may help understand conflicting evidence from larger clinical trials on MRAs<\/jats:styled-content> in patients with preserved EF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22528","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T00:49:37Z","timestamp":1458348577000},"page":"285-290","source":"Crossref","is-referenced-by-count":7,"title":["Vascular Effects of Eplerenone in Coronary Artery Disease With Preserved Ejection Fraction: A Double\u2010Blind, Randomized, Placebo\u2010Controlled Trial"],"prefix":"10.1002","volume":"39","author":[{"given":"Isabella","family":"Sudano","sequence":"first","affiliation":[{"name":"University Heart Center, Cardiology Clinic University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Naegele","sequence":"additional","affiliation":[{"name":"University Heart Center, Cardiology Clinic University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Roas","sequence":"additional","affiliation":[{"name":"University Heart Center, Cardiology Clinic University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"P\u00e9riat","sequence":"additional","affiliation":[{"name":"University Heart Center, Cardiology Clinic University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Frank","sequence":"additional","affiliation":[{"name":"University Heart Center, Cardiology Clinic University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey","family":"Kouroedov","sequence":"additional","affiliation":[{"name":"Center for Integrative Human Physiology University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Noll","sequence":"additional","affiliation":[{"name":"University Heart Center, Cardiology Clinic University Hospital Zurich Zurich Switzerland"},{"name":"Center for Integrative Human Physiology University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"L\u00fcscher","sequence":"additional","affiliation":[{"name":"University Heart Center, Cardiology Clinic University Hospital Zurich Zurich Switzerland"},{"name":"Center for Integrative Human Physiology University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Enseleit","sequence":"additional","affiliation":[{"name":"University Heart Center, Cardiology Clinic University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Ruschitzka","sequence":"additional","affiliation":[{"name":"University Heart Center, Cardiology Clinic University Hospital Zurich Zurich Switzerland"},{"name":"Center for Integrative Human Physiology University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas J.","family":"Flammer","sequence":"additional","affiliation":[{"name":"University Heart Center, Cardiology Clinic University Hospital Zurich Zurich 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