{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:49:06Z","timestamp":1773686946688,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>Following successful cavotricuspid isthmus (CTI<\/jats:styled-content>) ablation during typical atrial flutter (AFL<\/jats:styled-content>), anticoagulation therapy is usually withdrawn. However, potential subsequent atrial fibrillation (AF<\/jats:styled-content>) in these patients may increase embolic risk in the long term. Embolic rates in this setting have not been clearly established. Our aim was to determine the incidence of stroke\/systemic embolism following radiofrequency ablation of AFL<\/jats:styled-content>, particularly in those without a prior history of AF<\/jats:styled-content>.<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>After succesful AFL ablation, patients may suffer embolic complications in the long\u2010term follow\u2010up, mainly due to asymptomatic AF episodes.<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a retrospective analysis of all patients who underwent CTI<\/jats:styled-content> ablation due to AFL<\/jats:styled-content> in our center between 2006 and 2009.<\/jats:p><\/jats:sec>Results<\/jats:title>During the study period, 188 patients (mean age, 62.9\u2009\u00b1\u20098.6 years) underwent CTI<\/jats:styled-content> ablation; 120 without prior AF<\/jats:styled-content> were included in the study. At the end of the follow\u2010up period (mean, 5.0\u2009\u00b1\u20092.4 years), 56.7% of patients (68\/120) remained in sinus rhythm, 7\/120 experienced a recurrence of AFL<\/jats:styled-content>, and 45\/120 (38%) developed AF<\/jats:styled-content>. Ischemic stroke occurred in 11 patients and systemic embolism in 1. Of these patients, 5 had documented AF<\/jats:styled-content> following AFL<\/jats:styled-content> ablation. In the remaining 7 cases, previously undiagnosed AF<\/jats:styled-content> was subsequently diagnosed at the time of stroke\/embolism.<\/jats:p><\/jats:sec>Conclusions<\/jats:italic><\/jats:title>Patients with AFL<\/jats:styled-content> who undergo successful ablation are by no means free from embolic complications during long\u2010term follow\u2010up, mainly due to a high rate of AF<\/jats:styled-content> development. Given the difficulties in detecting AF<\/jats:styled-content> and the uncertainty about the temporal relation of AF<\/jats:styled-content> and stroke, oral anticoagulation may need to be continued in those patients with underlying stroke risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22538","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:11:12Z","timestamp":1459383072000},"page":"347-351","source":"Crossref","is-referenced-by-count":12,"title":["Stroke and Systemic Embolism After Successful Ablation of Typical Atrial Flutter"],"prefix":"10.1002","volume":"39","author":[{"given":"V\u00edctor","family":"Exp\u00f3sito","sequence":"first","affiliation":[{"name":"Arrhythmia Unit, Cardiology Service Marqu\u00e9s de Valdecilla University Hospital Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Rodr\u00edguez\u2010Entem","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Service Marqu\u00e9s de Valdecilla University Hospital Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Gonz\u00e1lez\u2010Enr\u00edquez","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Service Marqu\u00e9s de Valdecilla University Hospital Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Veiga","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Service Marqu\u00e9s de Valdecilla University Hospital Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Olavarri","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology Service Marqu\u00e9s de Valdecilla University Hospital Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J.","family":"Olalla","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Cardiology 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