{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:16:53Z","timestamp":1790651813309,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:00:00Z","timestamp":1462838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Abstract<\/jats:title>BACKGROUND<\/jats:title>Attempts to achieve rhythm control using direct\u2010current cardioversion (DCC<\/jats:styled-content>) are common in those with persistent atrial fibrillation (AF<\/jats:styled-content>). Although often successful, AF<\/jats:styled-content> recurs within 1 month in as many as 57% of patients. The aim of this study was to assess whether a baseline left atrial sphericity index (LASI<\/jats:styled-content>) acquired by 2\u2010dimensional transthoracic echocardiography (TTE<\/jats:styled-content>) could be used as a predictor of AF<\/jats:styled-content> recurrence after successful DCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>A baselline LASI assessed by 2D TTE can predict AF recurrence after successful DCC in patients with persistent AF.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 124 consecutive patients with persistent AF<\/jats:styled-content> lasting <120 days underwent successful DCC<\/jats:styled-content>. Other than \u03b2\u2010blockers, no other antiarrhythmic treatment was administered. Prior to DCC<\/jats:styled-content>, all patients underwent thorough TTE<\/jats:styled-content>, and LASI<\/jats:styled-content> was calculated as the fraction of the left atrial width\/length of the largest possible left atrial volume in a 4\u2010chamber view. The primary outcome was a TTE<\/jats:styled-content>\u2010estimated baseline LASI<\/jats:styled-content> as a predictor of AF<\/jats:styled-content> recurrence after successful DCC<\/jats:styled-content> for persistent AF<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Anatomically, a more spherical shape of the left atrium (LASI<\/jats:styled-content> >0.9) proved to be a strong and independent predictor of AF<\/jats:styled-content> recurrence, with an odds ratio between 4.1 (95% confidence interval: 1.6\u201011.9, P<\/jats:italic> = 0.005) and 7.6 (95% confidence interval: 3.3\u201019.7; P<\/jats:italic> = 7.2\u2009\u00d7\u200910\u22126<\/jats:sup>). The receiver operating characteristic curve indicated good power for distinguishing between recurring and nonrecurring AF<\/jats:styled-content>, and we chose a cutoff of 0.9 because high specificity was a priority for clinical reasons.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In conclusion, baseline LASI<\/jats:styled-content> >0.9 was associated with significantly greater AF<\/jats:styled-content> recurrence throughout the 12\u2010month follow\u2010up period.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22545","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T15:03:08Z","timestamp":1462892588000},"page":"406-412","source":"Crossref","is-referenced-by-count":20,"title":["Left Atrial Sphericity Index Predicts Early Recurrence of Atrial Fibrillation After Direct\u2010Current Cardioversion: An Echocardiographic Study"],"prefix":"10.1002","volume":"39","author":[{"given":"Armin","family":"Osmanagic","sequence":"first","affiliation":[{"name":"Department of Medical Research Odense University Hospital Svendborg Svendborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Epidemiology, Biostatistics and Biodemography, Department of Public Health University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azra","family":"Osmanagic","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussam M.","family":"Sheta","sequence":"additional","affiliation":[{"name":"Department of Medical Research Odense University Hospital Svendborg Svendborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina H.","family":"Vinther","sequence":"additional","affiliation":[{"name":"Department of Medical Research Odense University Hospital Svendborg Svendborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Egstrup","sequence":"additional","affiliation":[{"name":"Department of Medical Research Odense University Hospital Svendborg Svendborg 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