{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T18:06:17Z","timestamp":1771956377451,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:00:00Z","timestamp":1462838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>Coronary microcirculation dysfunction can occur in patients with chest pain suggestive of coronary artery disease (CAD<\/jats:styled-content>). The present study aimed to determine the diagnostic value of resting myocardial contrast echocardiography (MCE<\/jats:styled-content>) for early CAD<\/jats:styled-content> with myocardial microcirculation dysfunction by evaluating the continuous imaging time, peak time, and peak intensity.<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>Resting MCE is an effective and noninvasive method for evaluation of coronary microcirculation dysfunction in patients with early coronary artery disease.<\/jats:p><\/jats:sec>Methods<\/jats:title>The present study included 20 consecutive patients without obvious clinical evidence of early CAD<\/jats:styled-content> and 20 healthy volunteers. Resting MCE<\/jats:styled-content> was performed to evaluate the myocardial microcirculation perfusion, and the follow\u2010up evaluation of myocardial microcirculation perfusion was performed with technetium 99\u2009m 2\u2010methoxy\u2010isobutyl\u2010isonitrile (99m<\/jats:sup>Tc\u2010MIBI<\/jats:styled-content>) single\u2010photon emission computed tomography (SPECT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Peak intensity was significantly lower in patients with high risk of CAD<\/jats:styled-content> than in controls (P<\/jats:italic> < 0.0001). The peak time and continuous imaging time were significantly higher in patients with high risk of CAD<\/jats:styled-content> than in controls (P<\/jats:italic> < 0.0001). None of the 40 subjects experienced discomfort, such as cough and chest tightness, during the resting MCE<\/jats:styled-content> procedure, and the heart rate and blood pressure showed no abnormalities during the entire procedure. SPECT<\/jats:styled-content> imaging showed reversible myocardial perfusion reduction in 80% (16\/20) of the patients with high risk of CAD<\/jats:styled-content>. Abnormalities of heart rate and blood pressure and adverse reactions were noted during the process of SPECT<\/jats:styled-content> examination.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Resting MCE<\/jats:styled-content> is an effective and noninvasive method for detecting abnormalities of coronary microcirculation and can help in the clinical analysis, risk assessment, and treatment of early occult CAD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22548","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T15:03:08Z","timestamp":1462892588000},"page":"453-458","source":"Crossref","is-referenced-by-count":9,"title":["Resting Myocardial Contrast Echocardiography for the Evaluation of Coronary Microcirculation Dysfunction in Patients With Early Coronary Artery Disease"],"prefix":"10.1002","volume":"39","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ultrasound Navy General Hospital 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