{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:38:54Z","timestamp":1771303134122,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T00:00:00Z","timestamp":1471910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007497","name":"Biosense Webster Inc","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["N01-HC-95159"],"award-info":[{"award-number":["N01-HC-95159"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["N01-HC-95160"],"award-info":[{"award-number":["N01-HC-95160"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["N01-HC-95161"],"award-info":[{"award-number":["N01-HC-95161"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["N01-HC-95162"],"award-info":[{"award-number":["N01-HC-95162"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["N01-HC-95163"],"award-info":[{"award-number":["N01-HC-95163"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["N01-HC-95164"],"award-info":[{"award-number":["N01-HC-95164"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["N01-HC-95165"],"award-info":[{"award-number":["N01-HC-95165"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["N01-HC-95166"],"award-info":[{"award-number":["N01-HC-95166"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["N01-HC-95167"],"award-info":[{"award-number":["N01-HC-95167"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["N01-HC-95168"],"award-info":[{"award-number":["N01-HC-95168"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["N01-HC-95169"],"award-info":[{"award-number":["N01-HC-95169"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"crossref","award":["UL1-TR-000040"],"award-info":[{"award-number":["UL1-TR-000040"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"crossref","award":["UL1-TR-001079"],"award-info":[{"award-number":["UL1-TR-001079"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Background<\/jats:title>Time to intrinsicoid deflection (ID<\/jats:styled-content>), the time from onset of the QRS<\/jats:styled-content> complex to the peak of the R wave on the electrocardiogram, represents delayed ventricular activation and suggests that impaired myocardial function is present. It is unknown whether delayed time to ID<\/jats:styled-content> is predictive of future heart failure (HF<\/jats:styled-content>) events.<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>Delayed time to ID is predictive of future HF<\/jats:styled-content> events.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 6394 participants (mean age, 62\u2009\u00b1\u200910\u2009years; 54% women; 38% whites, 28% blacks, 22% Hispanics, 12% Chinese Americans) without clinically apparent cardiovascular disease or major ventricular conduction delay (QRS<\/jats:styled-content> \u2265120\u2009ms) from the Multi\u2010Ethnic Study of Atherosclerosis were included. Time to ID<\/jats:styled-content> was automatically measured from baseline electrocardiograms (2000\u20132002) as the maximum value in leads V5<\/jats:sub>\n<\/jats:styled-content> and V6<\/jats:sub>\n<\/jats:styled-content>. Cox regression was used to compute hazard ratios (HRs<\/jats:styled-content>) and 95% confidence intervals (CIs<\/jats:styled-content>) for the association between time to ID<\/jats:styled-content> and HF<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Over a median follow\u2010up of 11.2\u2009years, a total of 217 (3.4%) participants developed HF<\/jats:styled-content> (incidence rate per 1000 person\u2010years: 3.33, 95% CI<\/jats:styled-content>: 2.91\u20103.80). In a multivariable Cox regression analysis adjusted for demographics, cardiovascular risk factors, and potential confounders, each 10\u2010ms increase in maximum time to ID<\/jats:styled-content> was associated with an increased risk for HF<\/jats:styled-content> (HR<\/jats:styled-content>: 1.42, 95% CI<\/jats:styled-content>: 1.15\u20101.74). The results remained similar when stratified by age, sex, and race\/ethnicity.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Delayed time to ID is able to identify individuals at risk for developing HF<\/jats:styled-content> before major ventricular conduction delays (eg, bundle branch block) are evident.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22561","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T13:46:53Z","timestamp":1471960013000},"page":"531-536","source":"Crossref","is-referenced-by-count":14,"title":["Electrocardiographic Time to Intrinsicoid Deflection and Heart Failure: The Multi\u2010Ethnic Study of Atherosclerosis"],"prefix":"10.1002","volume":"39","author":[{"given":"Wesley T.","family":"O'Neal","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology Emory University School of Medicine Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waqas T.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology Wake Forest School of Medicine Winston\u2010Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saman","family":"Nazarian","sequence":"additional","affiliation":[{"name":"Section for Cardiac Electrophysiology, Division of Cardiology Johns Hopkins University School of Medicine Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Kawel\u2010Boehm","sequence":"additional","affiliation":[{"name":"Department of Radiology Kantonsspital Graubuenden Chur Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Bluemke","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences National Institutes of Health Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joao A.C.","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, and Department of Radiology Johns Hopkins University Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsayed Z.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology Wake Forest School of Medicine Winston\u2010Salem, North Carolina"},{"name":"Epidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention Wake Forest School of Medicine Winston\u2010Salem, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84882-778-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.03.045"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00160-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000141726.01302.83"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2015.01.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.000217"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs112"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80433-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.19.2138"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2008.05.015"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.11.1197"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320430047030"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2929"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr086"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-011-0004-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0736(05)80095-0"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22561","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T11:45:36Z","timestamp":1696592736000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,23]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1002\/clc.22561"],"URL":"https:\/\/doi.org\/10.1002\/clc.22561","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,23]]}}}