{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:04:08Z","timestamp":1789034648112,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>New\u2010onset persistent left bundle branch block (<jats:styled-content style=\"fixed-case\">NOP\u2010LBBB<\/jats:styled-content>) is one of the most common conduction disturbances after transcatheter aortic valve implantation (<jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content>). We hypothesized that <jats:styled-content style=\"fixed-case\">NOP\u2010LBBB<\/jats:styled-content> may have a clinically negative impact after <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content>. To find out, we conducted a systematic literature search of the <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PubMed<\/jats:styled-content> and Embase databases. Observational studies that reported clinical outcomes of <jats:styled-content style=\"fixed-case\">NOP\u2010LBBB<\/jats:styled-content> patients after <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> were included. The random\u2010effects model was used to combine odds ratios, risk ratios, or hazard ratios (<jats:styled-content style=\"fixed-case\">HRs<\/jats:styled-content>) with 95% confidence intervals. Adjusted <jats:styled-content style=\"fixed-case\">HRs<\/jats:styled-content> were utilized over unadjusted <jats:styled-content style=\"fixed-case\">HRs<\/jats:styled-content> or risk ratios when available. A total of 4049 patients (807 and 3242 patients with and without <jats:styled-content style=\"fixed-case\">NOP\u2010LBBB<\/jats:styled-content>, respectively) were included. Perioperative (in\u2010hospital or 30\u2010day) and midterm all\u2010cause mortality and midterm cardiovascular mortality were comparable between the groups. The <jats:styled-content style=\"fixed-case\">NOP\u2010LBBB<\/jats:styled-content> patients experienced a higher rate of permanent pacemaker implantation (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>: 2.09, 95% confidence interval: 1.12\u20103.90, <jats:italic>P<\/jats:italic> = 0.021, <jats:italic><jats:styled-content style=\"fixed-case\">I<\/jats:styled-content><\/jats:italic><jats:sup>2<\/jats:sup> = 83%) during midterm follow\u2010up. We found that <jats:styled-content style=\"fixed-case\">NOP\u2010LBBB<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> resulted in higher permanent pacemaker implantation but did not negatively affect the midterm prognosis. Therefore, careful observation during the follow\u2010up is required.<\/jats:p>","DOI":"10.1002\/clc.22567","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T09:37:30Z","timestamp":1468921050000},"page":"544-550","source":"Crossref","is-referenced-by-count":36,"title":["The Prognostic Impact of New\u2010Onset Persistent Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation: A Meta\u2010analysis"],"prefix":"10.1002","volume":"39","author":[{"given":"Tomo","family":"Ando","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Mount Sinai Beth Israel Medical Center, Icahn School of Medicine at Mount Sinai  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisato","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Shizuoka Medical Center  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the ALICE 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