{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:28:55Z","timestamp":1789957735756,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In a prospective study, cardiac <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CMR<\/jats:styled-content>) and intravascular ultrasound were performed in women with myocardial infarction (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>) and nonobstructive coronary artery disease (<jats:styled-content style=\"fixed-case\">MINOCA<\/jats:styled-content>). Forty participants underwent adenosine\u2010stress <jats:styled-content style=\"fixed-case\">CMR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">sCMR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Abnormal perfusion may co\u2010localize with ischemic late gadolinium enhancement (<jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>\u2010weighted signal hyperintensity (<jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>+), suggesting microvascular dysfunction contributed to <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Qualitative perfusion analysis was performed by 2 independent readers. Abnormal myocardial perfusion reserve index (<jats:styled-content style=\"fixed-case\">MPRI<\/jats:styled-content>) was defined as global average \u22641.84.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Abnormal rest perfusion was present in 10 patients (25%) and stress perfusion abnormalities in 25 (63%). Abnormal stress perfusion was not associated with <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content> but tended to occur with <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>+. Among patients with abnormal perfusion and <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content>, the <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content> pattern was ischemic in half. The locations of abnormal perfusion and <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content> matched in 75%, <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>+ in 100%. Abnormal stress perfusion was not associated with plaque disruption and matched in location in 63%. <jats:styled-content style=\"fixed-case\">MPRI<\/jats:styled-content> was abnormal in 10 patients (25%) and was not associated with <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>+ or plaque disruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abnormal perfusion on <jats:styled-content style=\"fixed-case\">sCMR<\/jats:styled-content> is common among women with <jats:styled-content style=\"fixed-case\">MINOCA<\/jats:styled-content>. Abnormal perfusion usually co\u2010localized with <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>+ when present. Variability in <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content> pattern leads to uncertainty about whether the finding of abnormal perfusion was cause or consequence of the tissue state leading to <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content>. Low <jats:styled-content style=\"fixed-case\">MPRI<\/jats:styled-content>, possibly indicating diffuse microvascular disease, was observed with and without <jats:styled-content style=\"fixed-case\">LGE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>+. Multiple mechanisms may lead to abnormal perfusion on <jats:styled-content style=\"fixed-case\">sCMR<\/jats:styled-content>. Microvascular dysfunction may contribute to the pathogenesis of and coexist with other causes of <jats:styled-content style=\"fixed-case\">MINOCA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22571","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T12:36:41Z","timestamp":1469536601000},"page":"596-602","source":"Crossref","is-referenced-by-count":52,"title":["Stress Cardiac <scp>MRI<\/scp> in Women With Myocardial Infarction and Nonobstructive Coronary Artery Disease"],"prefix":"10.1002","volume":"39","author":[{"given":"Rina","family":"Mauricio","sequence":"first","affiliation":[{"name":"Department of Medicine New York University School of Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monvadi B.","family":"Srichai","sequence":"additional","affiliation":[{"name":"Department of Medicine Georgetown University School of Medicine  Washington, 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