{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T05:36:11Z","timestamp":1791696971746,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Background<\/jats:title>Obesity is increasingly recognized as an important risk factor for coronary artery disease (CAD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>Patients with increased body mass index (BMI<\/jats:styled-content>) present at a younger age with symptomatic CAD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We analyzed data on 2137 consecutive patients admitted for treatment of CAD<\/jats:styled-content> proven on angiography from 2010 to 2013, excluding those with prior coronary intervention or bypass surgery.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean age was 64.1\u2009\u00b1\u200912.4\u2009years; 75% were male; 43.6% were overweight (BMI<\/jats:styled-content> 25\u201329.9\u2009kg\/m2<\/jats:sup>) and 31.6% were obese (BMI<\/jats:styled-content> \u226530\u2009kg\/m2<\/jats:sup>). Patients with BMI<\/jats:styled-content> \u226525\u2009kg\/m2<\/jats:sup> compared with <25\u2009kg\/m2<\/jats:sup> were more likely to have diabetes (24.5% vs 13.6%), hypertension (56.2% vs 45.5%), and hyperlipidemia (42.4% vs 31.6%; P<\/jats:italic> < 0.0001 for all). On multivariate analysis adjusted for sex and cardiovascular risk factors, patients in higher BMI<\/jats:styled-content> categories had lower mean age in a linear and stepwise fashion compared with those with normal BMI<\/jats:styled-content> (P<\/jats:italic> < 0.0001). For example, compared with patients with normal BMI<\/jats:styled-content>, those with BMI<\/jats:styled-content> of 35 to 39.9\u2009kg\/m2<\/jats:sup> were on average 9.2\u2009years younger (P<\/jats:italic> < 0.0001). Multivariate analysis examining the interaction between sex and BMI<\/jats:styled-content> produced similar results for effect of BMI<\/jats:styled-content> on age of presentation (P<\/jats:italic> = 0.97 for interaction).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>After multivariate adjustment, patients with increased BMI<\/jats:styled-content> presented at an earlier age with symptomatic CAD<\/jats:styled-content> compared with patients with normal BMI<\/jats:styled-content>. Primary prevention efforts in those with increased BMI<\/jats:styled-content> to reduce risk\u2010factor burden, including evidence\u2010based treatments for weight reduction, promise to reduce risk or delay onset of CAD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22576","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T09:37:00Z","timestamp":1468921020000},"page":"653-657","source":"Crossref","is-referenced-by-count":24,"title":["Association Between Body Mass Index and Age of Presentation With Symptomatic Coronary Artery Disease"],"prefix":"10.1002","volume":"39","author":[{"given":"Syed M.","family":"Atique","sequence":"first","affiliation":[{"name":"Department of Cardiology The Canberra Hospital Canberra Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Shadbolt","sequence":"additional","affiliation":[{"name":"College of Medicine, Biology and Environment Australian National University Canberra Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Marley","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Canberra Hospital Canberra Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-7663","authenticated-orcid":false,"given":"Ahmad","family":"Farshid","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Canberra Hospital Canberra Australia"},{"name":"College of Medicine, Biology and Environment Australian National University Canberra Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"79","article-title":"Global Status Report on Noncommunicable Diseases","volume":"2014","author":"World Health Organization","year":"2014","journal-title":"Switzerland: World Health Organization"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.732"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.67.5.968"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.16.1867"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61836-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes179"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.066"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.171016"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.14"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502821"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.1993.1014"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072515"},{"key":"e_1_2_6_15_1","first-page":"381","article-title":"Centers for Disease Control and Prevention. 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