{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:53:17Z","timestamp":1790250797550,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T00:00:00Z","timestamp":1472774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008976","name":"Sanofi-Aventis Korea Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008976","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Although the rate of in\u2010hospital ischemic events after myocardial infarction (\n                      <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                      ) has dramatically decreased, long\u2010term residual risk may remain substantial. However, most of the information on current residual risk is derived from highly selected randomized trials.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>In patients with previous MI and no prior ischemic stroke\/transient ischemic attack (TIA), residual ischemic risk increases over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using the international Reduction of Atherothrombosis for Continued Health (\n                      <jats:styled-content style=\"fixed-case\">REACH<\/jats:styled-content>\n                      ) registry, we analyzed baseline characteristics and 4\u2010year follow\u2010up of patients with previous\n                      <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                      and no history of stroke\/\n                      <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>\n                      to describe annual rates of recurrent ischemic events globally and by geography. The primary outcome was the composite of cardiovascular death,\n                      <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                      , or stroke. Multivariate analysis identified risk factors associated with recurrent ischemic events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from 16\u2003770 patients enrolled at 5587 sites in 44 countries were analyzed. The rate of the primary outcome increased annually from 4.7% during year 1 to reach a 4\u2010year rate of 15.1%. Compared with North America, Japan experienced lower ischemic event rates (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01), whereas Eastern Europe (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01) and the Middle East (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01) experienced higher ischemic event rates. The presence of congestive heart failure, polyvascular disease, diabetes, atrial fibrillation or flutter, and older age were associated with increased residual risk (all\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01). Statin use was associated with lower ischemic risk (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In this study, residual ischemic risk after\n                      <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\n                      accrued progressively up to 4 years of follow\u2010up, emphasizing the value of intensive secondary prevention strategies to minimize residual risk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.22583","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T12:57:53Z","timestamp":1472821073000},"page":"670-677","source":"Crossref","is-referenced-by-count":57,"title":["Residual Ischemic Risk and Its Determinants in Patients With Previous Myocardial Infarction and Without Prior Stroke or\n                    <scp>TIA<\/scp>\n                    : Insights From the\n                    <scp>REACH<\/scp>\n                    Registry"],"prefix":"10.1002","volume":"39","author":[{"given":"J\u00e9r\u00e9mie","family":"Abtan","sequence":"first","affiliation":[{"name":"French Alliance for Cardiovascular Clinical Trials (FACT), DHU\u2010FIRE, H\u00f4pital Bichat (Assistance Publique\u2013H\u00f4pitaux de Paris), Universit\u00e9 Paris\u2010Diderot, Sorbonne\u2010Paris Cit\u00e9 and INSERM U\u20101148  Paris France"},{"name":"H\u00f4pital Avicenne (Assitance Publique\u2013H\u00f4pitaux de Paris) and Universit\u00e9 Paris 13  Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-6245","authenticated-orcid":false,"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Heart &amp; Vascular Center and Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yedid","family":"Elbez","sequence":"additional","affiliation":[{"name":"French Alliance for Cardiovascular Clinical Trials (FACT), DHU\u2010FIRE, H\u00f4pital Bichat (Assistance Publique\u2013H\u00f4pitaux de Paris), Universit\u00e9 Paris\u2010Diderot, Sorbonne\u2010Paris Cit\u00e9 and INSERM U\u20101148  Paris France"},{"name":"H\u00f4pital Avicenne (Assitance Publique\u2013H\u00f4pitaux de Paris) and Universit\u00e9 Paris 13  Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Sorbets","sequence":"additional","affiliation":[{"name":"French Alliance for Cardiovascular Clinical Trials (FACT), DHU\u2010FIRE, H\u00f4pital Bichat (Assistance Publique\u2013H\u00f4pitaux de Paris), Universit\u00e9 Paris\u2010Diderot, Sorbonne\u2010Paris Cit\u00e9 and INSERM U\u20101148  Paris France"},{"name":"H\u00f4pital Avicenne (Assitance 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