{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:49:23Z","timestamp":1761562163383},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Remote ischemic preconditioning (RIPC<\/jats:styled-content>) has been studied in models of different cardiovascular entities. Recently, a beneficial effect of RIPC<\/jats:styled-content> on incidence of atrial fibrillation (AF<\/jats:styled-content>) in postsurgical patients has been suggested. However, the potential impact of RIPC<\/jats:styled-content> on electrophysiological\u2010 and thrombogenesis\u2010related parameters in the setting of paroxysmal nonvalvular AF<\/jats:styled-content> has not been investigated. The aim of the study is to answer the following questions: (1) Does RIPC<\/jats:styled-content> have impact on inducibility of AF<\/jats:styled-content> in patients with known paroxysmal AF<\/jats:styled-content>? If yes, what are the direct electrophysiological mechanisms of this phenomenon, and could RIPC<\/jats:styled-content> be implemented to reduce AF<\/jats:styled-content> burden? (2) Does RIPC<\/jats:styled-content> have the potential to minimize thrombogenic effects of simulated episodes of AF<\/jats:styled-content>? If so, what are inhibited components of thrombogenesis and can this be used to reduce thromboembolic risk related to paroxysmal AF<\/jats:styled-content>? The presented study is a 2\u2010arm, randomized, placebo\u2010controlled, double\u2010blinded, single\u2010center trial in a cohort of 146 patients with paroxysmal AF<\/jats:styled-content> referred for AF<\/jats:styled-content> ablation in sinus rhythm. The study will collect electrophysiological data such as variability of P\u2010wave morphology, atrial refractory period, conduction times, and inducibility\/sustainability of AF<\/jats:styled-content>. Furthermore, AF<\/jats:styled-content>\u2010induced prothrombotic processes will be analyzed by quantification of platelet aggregates, analysis of platelet function, and measurement of thrombogenesis\u2010related plasma markers. Moreover, the study will provide a unique bio\u2010database for further analysis of molecular and genetic mechanisms responsible for observed results.<\/jats:p>","DOI":"10.1002\/clc.22584","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T15:07:08Z","timestamp":1477321628000},"page":"631-635","source":"Crossref","is-referenced-by-count":3,"title":["Effect of remote ischemic preconditioning on electrophysiological and biomolecular parameters in nonvalvular paroxysmal atrial fibrillation (RIPPAF<\/scp> study): Rationale and study design of a randomized, controlled clinical trial"],"prefix":"10.1002","volume":"39","author":[{"given":"Jedrzej","family":"Kosiuk","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig Leipzig University Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Milani","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig Leipzig University Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Ueberham","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig Leipzig University Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Uhe","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig Leipzig University Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Stegmann","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig Leipzig University Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Hindricks","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig Leipzig University Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Bollmann","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center Leipzig Leipzig University Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,24]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv463"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4189"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009618"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2011.226415"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-306178"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302751"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005336"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2014.11.011"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2005.12.014"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.968859"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.10.003"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1413579"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1413534"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.11.083"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22584","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22584","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:09:38Z","timestamp":1696619378000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,24]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/clc.22584"],"URL":"https:\/\/doi.org\/10.1002\/clc.22584","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,24]]}}}