{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:23:11Z","timestamp":1784262191432,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Medical treatment is the main clinical strategy for controlling patients with chronic stable angina and improving their quality of life (<jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content>). Ivabradine treatment on top of metoprolol decreases angina symptoms and improves <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> in patients with stable angina and coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>). This is a post hoc analysis (636 <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> patients given ivabradine\/metoprolol free combination) of a prospective, noninterventional study that included 2403 patients with <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> and stable angina. Data were recorded at baseline at 1 and 4 months after inclusion. Patient <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> was assessed using the <jats:styled-content style=\"fixed-case\">EQ\u20105D<\/jats:styled-content> questionnaire. From baseline to study completion; ivabradine administration on top of metoprolol decreased heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) from 80.8\u2009\u00b1\u20099.6 to 64.2\u2009\u00b1 6.2\u2009bpm (<jats:italic>P<\/jats:italic> &lt; 0.001). Mean number of angina attacks decreased from 2.0\u2009\u00b1\u20092.0\/wk to 0.2\u2009\u00b1\u20090.6\/wk (<jats:italic>P<\/jats:italic> &lt; 0.001), whereas nitroglycerin consumption decreased from 1.4\u2009\u00b1\u20091.9 times\/wk to 0.1\u2009\u00b1\u20090.4 times\/wk (<jats:italic>P<\/jats:italic> &lt; 0.001). The percentage of patients in Canadian Cardiovascular Society angina class <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> decreased from 15.4% to 1.9% (<jats:italic>P<\/jats:italic> &lt; 0.001). The improvement of symptoms and angina class led to a significant 14.7\u2010point increase in <jats:styled-content style=\"fixed-case\">EQ\u20105D<\/jats:styled-content> questionnaire score (<jats:italic>P<\/jats:italic> &lt; 0.001). Patients with increased <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> showed greater improvement (<jats:italic>P<\/jats:italic> = 0.001). Adherence to treatment during the entire trial was high (98%). Ivabradine combined with metoprolol significantly decreased angina symptoms and use of nitroglycerin in patients with stable angina and <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>, leading to improved <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content>. The benefits observed with this combination explain the high rate of adherence to treatment.<\/jats:p>","DOI":"10.1002\/clc.22585","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T17:17:45Z","timestamp":1479921465000},"page":"697-702","source":"Crossref","is-referenced-by-count":13,"title":["Antianginal Efficacy of Ivabradine\/Metoprolol Combination in Patients With Stable Angina"],"prefix":"10.1002","volume":"39","author":[{"given":"John","family":"Zarifis","sequence":"first","affiliation":[{"name":"Cardiology Department George Papanikolaou General Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manolis","family":"Kallistratos","sequence":"additional","affiliation":[{"name":"Cardiology Department Asklepeion General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos","family":"Katsivas","sequence":"additional","affiliation":[{"name":"First Cardiology Department Korgialeneio\u2010Benakeio E.E.S. General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the investigators of the Prospective, Non\u2010interventional, Observational Study of the Antianginal Efficacy of Ivabradine During a 4\u2010Month Treatment of a Greek Population With Coronary Artery Disease","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-011-0402-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi586"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-011-6327-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22479"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn571"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.54.3.947585"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-6296(95)00038-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199711000-00002"},{"key":"e_1_2_6_10_1","first-page":"180","article-title":"The Greek version of the EuroQol (EQ\u20105D) instrument","volume":"18","author":"Yfantopoulos J.","year":"2001","journal-title":"Arch Hellen Med."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht384"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-200212000-00008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2009.084384"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61198-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.02.044"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318193dfce"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304880"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439584"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014695"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199916020-00003"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422511"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22585","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:03:54Z","timestamp":1696604634000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,23]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1002\/clc.22585"],"URL":"https:\/\/doi.org\/10.1002\/clc.22585","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,23]]}}}