{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:03:54Z","timestamp":1761102234119},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Vitamin D is suggested to reduce cardiovascular risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Circulating levels of plasma lipids and other cardiovascular risk factors may differ between statin\u2010treated patients with different vitamin D status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 3 age\u2010 and weight\u2010matched groups of men with elevated low\u2010density lipoprotein cholesterol (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010C) levels: vitamin D\u2013na\u00efve men with vitamin D insufficiency (group A, n\u2009=\u200918), men with vitamin D deficiency\/insufficiency effectively treated with vitamin D preparations (group B, n\u2009=\u200916), and vitamin D\u2013na\u00efve men with normal vitamin D status (group C, n\u2009=\u200916). All patients were then treated with atorvastatin (20\u2009mg daily) for 4 months. Plasma lipids, glucose homeostasis markers, and plasma levels of uric acid, high\u2010sensitivity C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">hsCRP<\/jats:styled-content>), homocysteine, and fibrinogen were assessed before and at the end of atorvastatin therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Study groups did not differ in baseline levels of plasma lipids. Men with vitamin D deficiency or insufficiency effectively treated with vitamin D preparations were characterized by decreased insulin sensitivity and higher circulating levels of <jats:styled-content style=\"fixed-case\">hsCRP<\/jats:styled-content>, homocysteine, and fibrinogen in comparison with the remaining groups of patients. Although atorvastatin decreased plasma levels of total cholesterol and <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010C to a similar extent in all study groups, its effect on uric acid, <jats:styled-content style=\"fixed-case\">hsCRP<\/jats:styled-content>, homocysteine, and fibrinogen was more pronounced in patients from groups B and C than in men from group A. Moreover, in patients with vitamin D insufficiency, atorvastatin impaired insulin sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The obtained results indicate that the strength of pleiotropic effects of atorvastatin depends on vitamin D status.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22593","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T13:24:45Z","timestamp":1474896285000},"page":"715-720","source":"Crossref","is-referenced-by-count":12,"title":["Different cardiometabolic effects of atorvastatin in men with normal vitamin D status and vitamin D insufficiency"],"prefix":"10.1002","volume":"39","author":[{"given":"Robert","family":"Krysiak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology Medical University of Silesia  Katowice 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